| Cell line name |
J.gamma1.WT |
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| Synonyms |
J.gamma1.WT-1; J.gamma1.wt |
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| Accession |
CVCL_6411 |
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| Resource Identification Initiative |
To cite this cell line use: J.gamma1.WT (RRID:CVCL_6411) |
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| Comments |
Population: Caucasian.
Transfected with: HGNC; 9065; PLCG1.
Transformant: ChEBI; CHEBI:132982; Acridine half-mustard dihydrochloride (6-chloro-9-[3-(2-chloroethylamino)propylamino]-2-methoxyacridine dihydrochloride; Acridine mutagen ICR 191).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084. |
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| Sequence variations |
- Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11491; SYK; Simple; p.Met34Hisfs*3 (c.98_99insG); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
|
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| Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_6410 (J.gamma1) |
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| Sex of cell |
Male |
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| Age at sampling |
14Y |
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| Category |
Cancer cell line |
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| STR profile |
Source(s): ATCC
Markers:
Run an STR similarity search on this cell line |
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| Publications | PubMed=11094067; DOI=10.1128/mcb.20.24.9149-9161.2000
Irvin B.J., Williams B.L., Nilson A.E., Maynor H.O., Abraham R.T.
Pleiotropic contributions of phospholipase C-gamma1 (PLC-gamma1) to T-cell antigen receptor-mediated signaling: reconstitution studies of a PLC-gamma1-deficient Jurkat T-cell line.
Mol. Cell. Biol. 20:9149-9161(2000) |
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| Cross-references |
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| Cell line collections (Providers) |
ATCC; CRL-2679
|
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| Cell line databases/resources |
CLO; CLO_0006986
CLO; CLO_0009837
cancercelllines; CVCL_6411
LINCS_LDP; LCL-2039
|
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| Biological sample resources |
BioSample; SAMN03471764
|
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| Encyclopedic resources |
Wikidata; Q54898431
|
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| Entry history |
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| Entry creation | 04-Apr-2012 |
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| Last entry update | 05-Oct-2023 |
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| Version number | 29 |
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