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Cellosaurus P116 (CVCL_6429)

[Text version]

Cell line name

P116

Accession

CVCL_6429

Resource Identification Initiative

To cite this cell line use: P116 (RRID:CVCL_6429)

Comments

Omics: SNP array analysis.
Derived from sampling site: Peripheral blood.

Sequence variations

Heterozygous for BAX p.Glu41Argfs (c.121delG) (ClinVar=VCV000009512) and p.Glu41Glyfs (c.121dupG) (ClinVar=VCV000009511) (from parent cell line).
Heterozygous for FBXW7 p.Arg505Cys (c.1513C>T) (ClinVar=VCV000069961) (from parent cell line).
Heterozygous for INPP5D p.Gln345Ter (c.1033C>T) and c.1097+1065_1097+1112del47 (from parent cell line).
Homozygous for MSH2 p.Arg711Ter (c.2131C>T) (from parent cell line).
Homozygous for MSH6 p.Phe1088Serfs*2 (c.3261delC) (from parent cell line).
Heterozygous for SYK p.Met34Hisfs*3 (c.98_99insG) (from parent cell line).
Heterozygous for TP53 p.Arg196Ter (c.586C>T) (ClinVar=VCV000043589) (from parent cell line).

Disease

Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_0367 (Jurkat E6.1)
Children:

CVCL_6430 (P116.cl39)

Sex of cell

Male

Age at sampling

14Y

Category

Cancer cell line

STR profile

Source(s): ATCC

Markers:

Amelogenin	X
CSF1PO	11,12
D5S818	9
D7S820	8,11.3
D13S317	8,12
D16S539	11
TH01	6,9.3
TPOX	8,10
vWA	18,19

Publications

PubMed=9488454; DOI=10.1128/MCB.18.3.1388
Williams B.L., Schreiber K.L., Zhang W., Wange R.L., Samelson L.E., Leibson P.J., Abraham R.T.
Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line.
Mol. Cell. Biol. 18:1388-1399(1998)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

Cross-references

Cell line collections

ATCC; CRL-2676

Cell line databases/resources

TOKU-E; 2820

Ontologies

CLO; CLO_0008292

Biological sample resources

BioSample; SAMN03471760

Chemistry resources

GDSC; 1330986
PharmacoDB; P116_1229_2019

Gene expression databases