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Cellosaurus Ishikawa (Heraklio) 02 ER- (CVCL_6543)

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Cell line name Ishikawa (Heraklio) 02 ER-
Synonyms Ishikawa(Heraklio)02ER-; ER-02 ISH
Accession CVCL_6543
Resource Identification Initiative To cite this cell line use: Ishikawa (Heraklio) 02 ER- (RRID:CVCL_6543)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Population: Japanese.
Microsatellite instability: Instable (MSI) (PubMed=31068700).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Heterozygous for PIK3R1 p.Leu570Pro (c.1709T>C) (CCLE).
Heterozygous for POLE p.Pro102Ser (c.304C>T) (CCLE).
Heterozygous for POLE p.Asn751fs (c.2252delA) (CCLE).
Heterozygous for PTEN p.Thr319fs*1 (c.950_953delTACT) (p.VL317fs) (V317fs*3) (CCLE).
Heterozygous for PTEN p.Glu288fs*3 (c.863delA) (CCLE).
Heterozygous for TP53 p.Asp49His (c.145G>C) (ClinVar=VCV000135948) (CCLE).
Heterozygous for TP53 p.Met246Val (c.736A>G) (ClinVar=VCV000100815) (CCLE).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North80.66
East Asian, South19.33
South Asian0
European, North0
European, South0
Disease Endometrial adenocarcinoma (NCIt: C7359)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2529 (Ishikawa)
Sex of cell Female
Age at sampling 39Y
Category Cancer cell line
STR profile Source(s): DepMap

Markers:
AmelogeninX
CSF1PO11,12
D3S135815,16,17
D5S81810,11,12
D7S8209,10
D8S117912,16
D13S3179,12,13
D16S5399
D18S5113,14,18,19,20
D21S1128
FGA20,21
Penta D10,11
Penta E11,12,18,19,20
TH019,10
TPOX8
vWA14,16,17,18

Run an STR similarity search on this cell line
Publications

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023
Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. III, Kalocsay M., Jane-Valbuena J., Gelfand E., Schweppe D.K., Jedrychowski M., Golji J., Porter D.A., Rejtar T., Wang Y.K., Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., Sellers W.R., Gygi S.P.
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

Cross-references
Cell line collections ECACC; 98032302 - Discontinued
Cell line databases/resources CCLE; ISHIKAWAHERAKLIO02ER_ENDOMETRIUM
Cell_Model_Passport; SIDM00037
DepMap; ACH-000961
LINCS_HMS; 50019
LINCS_LDP; LCL-1498
Ontologies CLO; CLO_0006967
Biological sample resources BioSample; SAMN10988025
Chemistry resources GDSC; 1240156
PharmacoDB; Ishikawa_Heraklio_02ER_668_2019
Gene expression databases ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM827371
GEO; GSM887164
GEO; GSM888236
Other Wikidata; Q54898302
Polymorphism and mutation databases LiGeA; CCLE_241
Progenetix; CVCL_6543
Entry history
Entry creation04-Apr-2012
Last entry update12-Jan-2021
Version number24