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Cellosaurus 11-18 (CVCL_6659)

[Text version]

Cell line name 11-18
Synonyms II-18
Accession CVCL_6659
Secondary accession CVCL_A596
Resource Identification Initiative To cite this cell line use: 11-18 (RRID:CVCL_6659)
Comments Population: Japanese.
Sequence variations Heterozygous for EGFR p.Leu858Arg (c.2573T>G) (ClinVar=VCV000016609) (PubMed=16105816).
HLA typing Source: PubMed=9023415
Class I
HLA-AA*02:01,24:02
HLA-BB*52:01,54:01
HLA-CC*01:02,12:01
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_D856 (11-18-ER1-7)CVCL_D857 (11-18-ER2-1)CVCL_D776 (11-18-GEF10-1)
CVCL_D777 (11-18-GEF20-1)CVCL_S745 (11-18/R)
Category Cancer cell line
STR profile Source(s): RCB; TKG

Markers:
AmelogeninX
CSF1PO7,12 (RCB)
12 (TKG)
D5S81810,12
D7S82011
D13S31712
D16S53910
TH017
TPOX11
vWA15,17

Run an STR similarity search on this cell line
Publications

PubMed=9023415; DOI=10.1006/cimm.1996.1062
Seki N., Hoshino T., Kikuchi M., Hayashi A., Itoh K.
HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating lymphocytes of patients with non-small cell lung cancer.
Cell. Immunol. 175:101-110(1997)

PubMed=9538136; DOI=10.3892/ijo.12.5.1103
Takaki T., Hiraki A., Uenaka A., Gomi S., Itoh K., Udono H., Shibuya A., Tsuji T., Sekiguchi S., Nakayama E.
Variable expression on lung cancer cell lines of HLA-A2-binding MAGE- 3 peptide recognized by cytotoxic T lymphocytes.
Int. J. Oncol. 12:1103-1109(1998)

PubMed=14581340
Yokoi S., Yasui K., Iizasa T., Imoto I., Fujisawa T., Inazawa J.
TERC identified as a probable target within the 3q26 amplicon that is detected frequently in non-small cell lung cancers.
Clin. Cancer Res. 9:4705-4713(2003)

PubMed=15746151; DOI=10.1093/hmg/ddi092
Izumi H., Inoue J., Yokoi S., Hosoda H., Shibata T., Sunamori M., Hirohashi S., Inazawa J., Imoto I.
Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers.
Hum. Mol. Genet. 14:997-1007(2005)

PubMed=16105816; DOI=10.1158/0008-5472.CAN-05-0331
Nagai Y., Miyazawa H., Huqun X., Tanaka T., Udagawa K., Kato M., Fukuyama S., Yokote A., Kobayashi K., Kanazawa M., Hagiwara K.
Genetic heterogeneity of the epidermal growth factor receptor in non-small cell lung cancer cell lines revealed by a rapid and sensitive detection system, the peptide nucleic acid-locked nucleic acid PCR clamp.
Cancer Res. 65:7276-7282(2005)

PubMed=19472407; DOI=10.1002/humu.21028
Blanco R., Iwakawa R., Tang M., Kohno T., Angulo B., Pio R., Montuenga L.M., Minna J.D., Yokota J., Sanchez-Cespedes M.
A gene-alteration profile of human lung cancer cell lines.
Hum. Mutat. 30:1199-1206(2009)

PubMed=22313637; DOI=10.4161/cbt.19238
Takata M., Chikumi H., Miyake N., Adachi K., Kanamori Y., Yamasaki A., Igishi T., Burioka N., Nanba E., Shimizu E.
Lack of AKT activation in lung cancer cells with EGFR mutation is a novel marker of cetuximab sensitivity.
Cancer Biol. Ther. 13:369-378(2012)

PubMed=22815900; DOI=10.1371/journal.pone.0041017
Tabara K., Kanda R., Sonoda K., Kubo T., Murakami Y., Kawahara A., Azuma K., Abe H., Kage M., Yoshinaga A., Tahira T., Hayashi K., Arao T., Nishio K., Rosell R., Kuwano M., Ono M.
Loss of activating EGFR mutant gene contributes to acquired resistance to EGFR tyrosine kinase inhibitors in lung cancer cells.
PLoS ONE 7:E41017-E41017(2012)

Cross-references
Cell line collections RCB; RCB2093
TKG; TKG 0177
Cell line databases/resources CGH-DB; 201-1
CGH-DB; 9163-4
Ontologies CLO; CLO_0050051
Biological sample resources BioSample; SAMN03472059
Other Wikidata; Q54897419
Polymorphism and mutation databases Cosmic; 889084
Cosmic; 946048
Cosmic; 1066156
Cosmic; 1239901
Cosmic; 1336877
Cosmic; 1656892
Cosmic; 1731372
Cosmic; 2125265
Entry history
Entry creation04-Apr-2012
Last entry update29-Oct-2020
Version number13