ID   LS174T-HM7
AC   CVCL_6670
SY   HM7; HM-7; HM 7; LS174T-High Mucin 7
DR   BTO; BTO:0002921
DR   EFO; EFO_0006787
DR   ArrayExpress; E-MTAB-2706
DR   BioSample; SAMN03472364
DR   cancercelllines; CVCL_6670
DR   ColonAtlas; HM7
DR   EGA; EGAS00001000610
DR   PharmacoDB; HM7_551_2019
DR   Wikidata; Q54903055
RX   PubMed=1999484;
RX   PubMed=3664476;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=26589293;
CC   Population: Caucasian.
CC   Characteristics: Produces high amount of mucin in culture (PubMed=3664476).
CC   HLA typing: A*30:01,30:01; B*15:34,35:03; C*04:01,06:02; DQB1*05:01,05:01; DRB1*01:01,01:01 (PubMed=26589293).
CC   Sequence variation: Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45Phe (c.134C>T); ClinVar=VCV000017588; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (from parent cell line).
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
CC   Cell type: Epithelial cell of colon; CL=CL_0011108.
ST   Source(s): PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 10,13
ST   D13S317: 10,11
ST   D16S539: 11,13
ST   D18S51: 11,12
ST   D21S11: 29,31
ST   D3S1358: 16,17
ST   D5S818: 11,16
ST   D7S820: 10.3,11
ST   D8S1179: 12,16
ST   FGA: 21,22
ST   Penta D: 10
ST   Penta E: 15,16
ST   TH01: 6,7
ST   TPOX: 8,9
ST   vWA: 15,18
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1384 ! LS174T
SX   Female
AG   58Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 22
//
RX   PubMed=1999484; DOI=10.1172/JCI115063;
RA   Bresalier R.S., Niv Y., Byrd J.C., Duh Q.-Y., Toribara N.W.,
RA   Rockwell R.W., Dahiya R., Kim Y.S.;
RT   "Mucin production by human colonic carcinoma cells correlates with
RT   their metastatic potential in animal models of colon cancer
RT   metastasis.";
RL   J. Clin. Invest. 87:1037-1045(1991).
//
RX   PubMed=3664476;
RA   Kuan S.-F., Byrd J.C., Basbaum C.B., Kim Y.S.;
RT   "Characterization of quantitative mucin variants from a human colon
RT   cancer cell line.";
RL   Cancer Res. 47:5715-5724(1987).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S.,
RA   Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G.,
RA   Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J.,
RA   Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L.,
RA   Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J.,
RA   Settleman J., Seshagiri S., Zhang Z.-M.;
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M.,
RA   Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S.,
RA   Neve R.M.;
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5;
RA   Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P.,
RA   Loewer M., Sahin U., Castle J.C.;
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//