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Cellosaurus MCF-7N (CVCL_6673)

[Text version]
Cell line name MCF-7N
Synonyms MCF-7 N; MCF-7n
Accession CVCL_6673
Resource Identification Initiative To cite this cell line use: MCF-7N (RRID:CVCL_6673)
Comments Population: Caucasian.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Children:
CVCL_6674 (MCF-7TN-R)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=10811993; DOI=10.3892/ijo.16.6.1179
Burow M.E., Weldon C.B., Chiang T.-C., Tang Y., Collins-Burow B.M., Rolfe K., Li S.-F., McLachlan J.A., Beckman B.S.
Differences in protein kinase C and estrogen receptor alpha, beta expression and signaling correlate with apoptotic sensitivity of MCF-7 breast cancer cell variants.
Int. J. Oncol. 16:1179-1187(2000)

PubMed=15138590; DOI=10.3892/ijo.24.6.1473
Weldon C.B., Parker A.P., Patten D., Elliott S., Tang Y., Frigo D.E., Dugan C.M., Coakley E.L., Butler N.N., Clayton J.L., Alam J., Curiel T.J., Beckman B.S., Jaffe B.M., Burow M.E.
Sensitization of apoptotically-resistant breast carcinoma cells to TNF and TRAIL by inhibition of p38 mitogen-activated protein kinase signaling.
Int. J. Oncol. 24:1473-1480(2004)

Cross-references
Cell line databases/resources cancercelllines; CVCL_6673
Encyclopedic resources Wikidata; Q54904408
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number20