ID   MCF-7N
AC   CVCL_6673
SY   MCF-7 N; MCF-7n
DR   cancercelllines; CVCL_6673
DR   Wikidata; Q54904408
RX   PubMed=10811993;
RX   PubMed=15138590;
CC   Population: Caucasian.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0031 ! MCF-7
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 20
//
RX   PubMed=10811993; DOI=10.3892/ijo.16.6.1179;
RA   Burow M.E., Weldon C.B., Chiang T.-C., Tang Y., Collins-Burow B.M.,
RA   Rolfe K., Li S.-F., McLachlan J.A., Beckman B.S.;
RT   "Differences in protein kinase C and estrogen receptor alpha, beta
RT   expression and signaling correlate with apoptotic sensitivity of MCF-7
RT   breast cancer cell variants.";
RL   Int. J. Oncol. 16:1179-1187(2000).
//
RX   PubMed=15138590; DOI=10.3892/ijo.24.6.1473;
RA   Weldon C.B., Parker A.P., Patten D., Elliott S., Tang Y., Frigo D.E.,
RA   Dugan C.M., Coakley E.L., Butler N.N., Clayton J.L., Alam J.,
RA   Curiel T.J., Beckman B.S., Jaffe B.M., Burow M.E.;
RT   "Sensitization of apoptotically-resistant breast carcinoma cells to
RT   TNF and TRAIL by inhibition of p38 mitogen-activated protein kinase
RT   signaling.";
RL   Int. J. Oncol. 24:1473-1480(2004).
//