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Cellosaurus PK-45P (CVCL_6749)

[Text version]
Cell line name PK-45P
Synonyms PK-45 P; PK45P
Accession CVCL_6749
Resource Identification Initiative To cite this cell line use: PK-45P (RRID:CVCL_6749)
Comments Population: Japanese.
Omics: Metabolome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by RNAseq.
Sequence variations
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Homozygous (from autologous cell line PK-45H).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*24:02,33:03
HLA-BB*15:18,44:03
HLA-CC*07:04,14:03
Class II
HLA-DQDQA1*01:02,03:02
DQB1*06:04,06:04
HLA-DRDRB1*04:01,13:02
Disease Pancreatic carcinoma (NCIt: C3850)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_6748 ! PK-45H
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=25877200; RCB; TKG

Markers:
AmelogeninX
CSF1PO9,10
D3S135815
D5S81810,12
D7S82011
D8S117910,13
D13S3179,11
D16S53911,12
D18S5117
D21S1131.2,32.2
FGA23,24
Penta D12,13
Penta E5,15
TH019
TPOX8,11 (PubMed=25877200; RCB)
11 (TKG)
vWA16,18 (RCB)
18 (PubMed=25877200; TKG)

Run an STR similarity search on this cell line
Publications

PubMed=11115575; DOI=10.3892/or.8.1.89
Sun C.-L., Yamato T., Furukawa T., Ohnishi Y., Kijima H., Horii A.
Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines.
Oncol. Rep. 8:89-92(2001)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26216984; DOI=10.1073/pnas.1501605112
Daemen A., Peterson D., Sahu N., McCord R., Du X.-N., Liu B., Kowanetz K., Hong R., Moffat J., Gao M., Boudreau A., Mroue R., Corson L., O'Brien T., Qing J., Sampath D., Merchant M., Yauch R.L., Manning G., Settleman J., Hatzivassiliou G., Evangelista M.
Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors.
Proc. Natl. Acad. Sci. U.S.A. 112:E4410-E4417(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

Cross-references
Cell line collections (Providers) RCB; RCB2141
TKG; TKG 0493
Cell line databases/resources CLO; CLO_0050107
cancercelllines; CVCL_6749
Cell_Model_Passport; SIDM01319
Biological sample resources BioSample; SAMN03472015
BioSample; SAMN03472900
Chemistry resources PharmacoDB; PK45P_1267_2019
Encyclopedic resources Wikidata; Q54947443
Experimental variables resources EFO; EFO_0006735
Gene expression databases ArrayExpress; E-MTAB-2706
Polymorphism and mutation databases Cosmic; 1066183
Cosmic; 1644304
Sequence databases EGA; EGAS00001000610
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number23