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Cellosaurus WM239A (CVCL_6795)

[Text version]

Cell line name WM239A
Synonyms WM-239A; WM-239-A; WM 239-A; WM 239A; WM-239; WM239; WM 239; WC00044
Accession CVCL_6795
Resource Identification Initiative To cite this cell line use: WM239A (RRID:CVCL_6795)
Comments Part of: Wistar Institute melanoma cell line collection.
Omics: Transcriptome analysis.
Sequence variations Heterozygous for BRAF p.Val600Asp (c.1799_1800delTGinsAT) (Wistar).
Hemizygous for PTEN deletion (Wistar).
Disease Melanoma (NCIt: C3224)
Derived from metastatic site: Lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_VS31 (WM239A HmR)
Originate from same individual CVCL_0040 ! WM115
CVCL_L033 ! WM165-1
CVCL_RN55 ! WM165-2
CVCL_RN56 ! WM239B
CVCL_RN57 ! WM266-1
CVCL_RN58 ! WM266-2
CVCL_RN59 ! WM266-3
CVCL_2765 ! WM266-4
Sex of cell Female
Age at sampling 55Y
Category Cancer cell line
STR profile Source(s): Wistar

Markers:
AmelogeninX
CSF1PO11,12
D5S81812,13
D7S8207,8
D13S31711,12
D16S53911,12
D21S1128,29
TH017,9
TPOX8,11
vWA15,17

Run an STR similarity search on this cell line
Web pages https://www.wistar.org/our-scientists/meenhard-herlyn
http://www.rockland-inc.com/Product.aspx?id=51751
Publications

PubMed=3856042; DOI=10.1093/jnci/74.2.283
Herlyn M., Balaban G., Bennicelli J.L., Guerry D. IV, Halaban R., Herlyn D., Elder D.E., Maul G.G., Steplewski Z., Nowell P.C., Clark W.H., Koprowski H.
Primary melanoma cells of the vertical growth phase: similarities to metastatic cells.
J. Natl. Cancer Inst. 74:283-289(1985)

PubMed=4053039
Herlyn M., Thurin J., Balaban G., Bennicelli J.L., Herlyn D., Elder D.E., Bondi E., Guerry D. IV, Nowell P.C., Clark W.H., Koprowski H.
Characteristics of cultured human melanocytes isolated from different stages of tumor progression.
Cancer Res. 45:5670-5676(1985)

PubMed=3020539; DOI=10.1073/pnas.83.19.7197
Westermark B., Johnsson A., Paulsson Y., Betsholtz C., Heldin C.-H., Herlyn M., Rodeck U., Koprowski H.
Human melanoma cell lines of primary and metastatic origin express the genes encoding the chains of platelet-derived growth factor (PDGF) and produce a PDGF-like growth factor.
Proc. Natl. Acad. Sci. U.S.A. 83:7197-7200(1986)

PubMed=2253310; DOI=10.1007/BF00046337
Herlyn M.
Human melanoma: development and progression.
Cancer Metastasis Rev. 9:101-112(1990)

PubMed=15009714; DOI=10.1046/j.0022-202X.2004.22243.x
Tsao H., Goel V., Wu H., Yang G., Haluska F.G.
Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma.
J. Invest. Dermatol. 122:337-341(2004)

PubMed=16827748; DOI=10.1111/j.1600-0749.2006.00322.x
Hoek K.S., Schlegel N.C., Brafford P., Sucker A., Ugurel S., Kumar R., Weber B.L., Nathanson K.L., Phillips D.J., Herlyn M., Schadendorf D., Dummer R.
Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature.
Pigment Cell Res. 19:290-302(2006)

PubMed=18632627; DOI=10.1158/0008-5472.CAN-08-0235
Smalley K.S.M., Contractor R., Nguyen T.K., Xiao M., Edwards R., Muthusamy V., King A.J., Flaherty K.T., Bosenberg M., Herlyn M., Nathanson K.L.
Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression.
Cancer Res. 68:5743-5752(2008)

Cross-references
Cell line collections Coriell; WC00044 - Discontinued
Cell line databases/resources Cell_Model_Passport; SIDM00978
GDSC; 1240225
Ontologies BTO; BTO:0003474
Gene expression databases GEO; GSM109034
GEO; GSM188232
GEO; GSM188262
GEO; GSM188321
Other Wikidata; Q54994215
Polymorphism and mutation databases Cosmic; 888850
Cosmic; 928690
Cosmic; 972260
Cosmic; 1155288
Cosmic; 1155564
Cosmic; 1303069
Cosmic; 1477413
IARC_TP53; 24993
Entry history
Entry creation04-Apr-2012
Last entry updated05-Jul-2019
Version number17