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Cellosaurus WM3211 (CVCL_6797)

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Cell line name WM3211
Synonyms WM-3211; WM 3211; WC00045; EST79
Accession CVCL_6797
Resource Identification Initiative To cite this cell line use: WM3211 (RRID:CVCL_6797)
Comments Part of: Wistar Institute melanoma cell line collection.
Omics: Array-based CGH.
Omics: Deep exome analysis.
Omics: Transcriptome analysis.
Sequence variations CDKN2A p.Gln50Ter (c.148C>T) (PubMed=23851445).
KIT p.Leu576Pro (c.1727T>C) (PubMed=23851445; PubMed=24576830; Wistar).
TP53 p.Cys242Gly (c.724T>G) (PubMed=17260012; PubMed=23851445).
HLA typing Source: PubMed=15592718
Class I
HLA-AA*03:01,24:02
HLA-BB*07:02
HLA-CC*07:02
Class II
HLA-DPDPB1*04:01
HLA-DQDQB1*06:02,03:01:01
HLA-DRDRB1*04:01:01,15:01
Disease Acral lentiginous melanoma (NCIt: C4022)
Derived from metastatic site: Lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 34Y
Category Cancer cell line
STR profile Source(s): ESTDAB; Wistar

Markers:
AmelogeninX
CSF1PO13
D2S133820,24
D3S135815,16
D5S81811
D7S82010,12
D8S117910,11
D13S31712
D16S53912
D18S5112
D19S43313,14
D21S1129,31.2
FGA20
TH016,9.3
TPOX11
vWA14,17

Run an STR similarity search on this cell line
Web pages https://www.wistar.org/our-scientists/meenhard-herlyn
http://www.rockland-inc.com/Product.aspx?id=51798
Publications

PubMed=15592718; DOI=10.1007/s00262-004-0561-5
Rodriguez T., Mendez R., Roberts C.H., Ruiz-Cabello F., Dodi I.A., Lopez Nevot M.A., Paco L., Maleno I., Marsh S.G.E., Pawelec G., Garrido F.
High frequency of homozygosity of the HLA region in melanoma cell lines reveals a pattern compatible with extensive loss of heterozygosity.
Cancer Immunol. Immunother. 54:141-148(2005)

PubMed=16827748; DOI=10.1111/j.1600-0749.2006.00322.x
Hoek K.S., Schlegel N.C., Brafford P., Sucker A., Ugurel S., Kumar R., Weber B.L., Nathanson K.L., Phillips D.J., Herlyn M., Schadendorf D., Dummer R.
Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature.
Pigment Cell Res. 19:290-302(2006)

PubMed=17260012; DOI=10.1038/sj.onc.1210252
Jonsson G., Dahl C., Staaf J., Sandberg T., Bendahl P.-O., Ringner M., Guldberg P., Borg A.
Genomic profiling of malignant melanoma using tiling-resolution arrayCGH.
Oncogene 26:4738-4748(2007)

PubMed=18632627; DOI=10.1158/0008-5472.CAN-08-0235
Smalley K.S.M., Contractor R., Nguyen T.K., Xiao M., Edwards R., Muthusamy V., King A.J., Flaherty K.T., Bosenberg M., Herlyn M., Nathanson K.L.
Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression.
Cancer Res. 68:5743-5752(2008)

PubMed=22578220; DOI=10.1111/j.1755-148X.2012.01016.x
Furney S.J., Turajlic S., Fenwick K., Lambros M.B., MacKay A., Ricken G., Mitsopoulos C., Kozarewa I., Hakas J., Zvelebil M., Lord C.J., Ashworth A., Reis-Filho J.S., Herlyn M., Murata H., Marais R.
Genomic characterisation of acral melanoma cell lines.
Pigment Cell Melanoma Res. 25:488-492(2012)

PubMed=23851445; DOI=10.1158/1541-7786.MCR-13-0006
Dahl C., Christensen C., Jonsson G., Lorentzen A., Skjodt M.L., Borg A., Pawelec G., Guldberg P.
Mutual exclusivity analysis of genetic and epigenetic drivers in melanoma identifies a link between p14 ARF and RARbeta signaling.
Mol. Cancer Res. 11:1166-1178(2013)

PubMed=24576830; DOI=10.1158/0008-5472.CAN-13-2625
Nissan M.H., Pratilas C.A., Jones A.M., Ramirez R., Won H., Liu C., Tiwari S., Kong L., Hanrahan A.J., Yao Z., Merghoub T., Ribas A., Chapman P.B., Yaeger R., Taylor B.S., Schultz N., Berger M.F., Rosen N., Solit D.B.
Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence.
Cancer Res. 74:2340-2350(2014)

Cross-references
Cell line collections Coriell; WC00045 - Discontinued
Cell line databases/resources ESTDAB; ESTDAB-079
Gene expression databases GEO; GSM109036
GEO; GSM156008
GEO; GSM185194
GEO; GSM185195
GEO; GSM188070
GEO; GSM188122
GEO; GSM188195
GEO; GSM188210
GEO; GSM188216
GEO; GSM188233
GEO; GSM188263
GEO; GSM188286
GEO; GSM188295
GEO; GSM188322
Other Wikidata; Q54994241
Polymorphism and mutation databases Cosmic; 972286
Cosmic; 1047655
Cosmic; 1155289
Cosmic; 1155541
Cosmic; 1284919
Cosmic; 1303071
Cosmic; 2144978
Cosmic; 2159443
Cosmic; 2163806
IARC_TP53; 26082
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2019
Version number23