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Cellosaurus WM46 (CVCL_6803)

[Text version]

Cell line name WM46
Synonyms WM-46; WM 46; WC00069
Accession CVCL_6803
Resource Identification Initiative To cite this cell line use: WM46 (RRID:CVCL_6803)
Comments Part of: Wistar Institute melanoma cell line collection.
Characteristics: Highly pigmented.
Omics: Transcriptome analysis.
Caution: The reported STR profile from Wistar of this cell line was changed at one point between February 2016 when we retrieved them and entered them in the Cellosaurus and May 2018. The major changes were: D13S317: 11,13->14, D8S1179: 13,14->14 and FGA: 22,23,28->23.
Sequence variations Heterozygous for BRAF p.Val600Glu (c.1799T>A) (ClinVar=VCV000013961) (PubMed=18632627; Wistar).
CDK4 p.Arg24Cys (c.70C>T) (ClinVar=VCV000016928) (Wistar).
Hemizygous for PTEN deletion (Wistar).
Disease Melanoma (NCIt: C3224)
Derived from metastatic site: Skin.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 43Y
Category Cancer cell line
STR profile Source(s): Wistar

Markers:
AmelogeninX
CSF1PO11
D2S133817,18
D3S135815,17
D5S81812
D7S82011
D8S117914
D13S31714
D16S53911,14
D18S5119,20
D19S43313,14
D21S1129,30
FGA23
TH016
TPOX11
vWA17,19

Run an STR similarity search on this cell line
Web pages https://www.wistar.org/our-scientists/meenhard-herlyn
http://www.rockland-inc.com/Product.aspx?id=51952
Publications

PubMed=4053039
Herlyn M., Thurin J., Balaban G., Bennicelli J.L., Herlyn D., Elder D.E., Bondi E., Guerry D. IV, Nowell P.C., Clark W.H., Koprowski H.
Characteristics of cultured human melanocytes isolated from different stages of tumor progression.
Cancer Res. 45:5670-5676(1985)

PubMed=18632627; DOI=10.1158/0008-5472.CAN-08-0235
Smalley K.S.M., Contractor R., Nguyen T.K., Xiao M., Edwards R., Muthusamy V., King A.J., Flaherty K.T., Bosenberg M., Herlyn M., Nathanson K.L.
Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression.
Cancer Res. 68:5743-5752(2008)

PubMed=18790768; DOI=10.1158/1535-7163.MCT-08-0431
Smalley K.S.M., Lioni M., Dalla Palma M., Xiao M., Desai B., Egyhazi S., Hansson J., Wu H., King A.J., Van Belle P., Elder D.E., Flaherty K.T., Herlyn M., Nathanson K.L.
Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomas.
Mol. Cancer Ther. 7:2876-2883(2008)

Cross-references
Cell line collections Coriell; WC00069 - Discontinued
Gene expression databases GEO; GSM186489
GEO; GSM186490
Other Wikidata; Q54994306
Polymorphism and mutation databases Cosmic; 1155269
Cosmic; 1155552
Cosmic; 1187582
Cosmic; 1303076
Entry history
Entry creation04-Apr-2012
Last entry update02-Jul-2020
Version number18