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Cellosaurus WM88 (CVCL_6805)

[Text version]

Cell line name WM88
Synonyms WM-88; WM 88; WC00123
Accession CVCL_6805
Resource Identification Initiative To cite this cell line use: WM88 (RRID:CVCL_6805)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: Wistar Institute melanoma cell line collection.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Caution: The reported STR profile from Wistar of this cell line was changed at one point between February 2016 when we retrieved them and entered them in the Cellosaurus and May 2018. The major changes were: Amelogenin: X,Y->X.
Sequence variations Heterozygous for BRAF p.Val600Glu (c.1799T>A) (Wistar; PubMed=24576830).
Disease Melanoma (NCIt: C3224)
Derived from metastatic site: Not specified.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): Wistar

Markers:
AmelogeninX
CSF1PO10
D2S133819
D3S135815
D5S81812,13
D7S8208,10
D8S117913,15
D13S31710,13
D16S53911,13
D18S5115,19
D19S43312,13
D21S1129,30
FGA20,21
TH019.3
TPOX12
vWA18

Run an STR similarity search on this cell line
Web pages https://www.wistar.org/our-scientists/meenhard-herlyn
http://www.rockland-inc.com/Product.aspx?id=51919
Publications

PubMed=16827748; DOI=10.1111/j.1600-0749.2006.00322.x
Hoek K.S., Schlegel N.C., Brafford P., Sucker A., Ugurel S., Kumar R., Weber B.L., Nathanson K.L., Phillips D.J., Herlyn M., Schadendorf D., Dummer R.
Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature.
Pigment Cell Res. 19:290-302(2006)

PubMed=18632627; DOI=10.1158/0008-5472.CAN-08-0235
Smalley K.S.M., Contractor R., Nguyen T.K., Xiao M., Edwards R., Muthusamy V., King A.J., Flaherty K.T., Bosenberg M., Herlyn M., Nathanson K.L.
Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression.
Cancer Res. 68:5743-5752(2008)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=24576830; DOI=10.1158/0008-5472.CAN-13-2625
Nissan M.H., Pratilas C.A., Jones A.M., Ramirez R., Won H., Liu C., Tiwari S., Kong L., Hanrahan A.J., Yao Z., Merghoub T., Ribas A., Chapman P.B., Yaeger R., Taylor B.S., Schultz N., Berger M.F., Rosen N., Solit D.B.
Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence.
Cancer Res. 74:2340-2350(2014)

Cross-references
Cell line collections Coriell; WC00123 - Discontinued
Cell line databases/resources CCLE; WM88_SKIN
SKY/M-FISH/CGH; 4948
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM109046
GEO; GSM188065
GEO; GSM188117
GEO; GSM188190
GEO; GSM188205
GEO; GSM188212
GEO; GSM188236
GEO; GSM188266
GEO; GSM188281
GEO; GSM188290
GEO; GSM188325
GEO; GSM887739
GEO; GSM888834
GEO; GSM952589
Other Wikidata; Q54994333
Polymorphism and mutation databases Cosmic; 1155563
Cosmic; 1303080
Cosmic; 1669265