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Cellosaurus WM983A (CVCL_6808)

[Text version]
Cell line name WM983A
Synonyms WM-983A; WM 983A; WM983-A; WC00048
Accession CVCL_6808
Resource Identification Initiative To cite this cell line use: WM983A (RRID:CVCL_6808)
Comments Part of: Wistar Institute melanoma cell line collection.
Population: Caucasian.
Omics: Transcriptome analysis by microarray.
Caution: The reported STR profile from Wistar of this cell line was changed at one point between February 2016 when we retrieved them and entered them in the Cellosaurus and May 2018. The major changes were: Amelogenin: X,Y->X, CSF1PO: 10,11->11, D13S317: 11,12->12, D5S818: 10,11->11 and D7S820: 10,11->11.
Sequence variations
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_6809 ! WM983B
CVCL_A338 ! WM983C
Sex of cell Male
Age at sampling 54Y
Category Cancer cell line
STR profile Source(s): Wistar

Markers:
AmelogeninX
CSF1PO11
D2S133825,27
D3S135817
D5S81811
D7S82011
D8S11798,13
D13S31712
D16S53911,12
D18S5114
D19S43310,14
D21S1129,32.2
FGA20,23
TH016
TPOX11
vWA17

Run an STR similarity search on this cell line
Web pages https://www.wistar.org/our-scientists/meenhard-herlyn
Publications

PubMed=2253310; DOI=10.1007/BF00046337
Herlyn M.
Human melanoma: development and progression.
Cancer Metastasis Rev. 9:101-112(1990)

PubMed=2068080; DOI=10.1073/pnas.88.14.6028
Cornil I., Theodorescu D., Man S., Herlyn M., Jambrosic J.A., Kerbel R.S.
Fibroblast cell interactions with human melanoma cells affect tumor cell growth as a function of tumor progression.
Proc. Natl. Acad. Sci. U.S.A. 88:6028-6032(1991)

PubMed=16827748; DOI=10.1111/j.1600-0749.2006.00322.x
Hoek K.S., Schlegel N.C., Brafford P., Sucker A., Ugurel S., Kumar R., Weber B.L., Nathanson K.L., Phillips D.J., Herlyn M., Schadendorf D., Dummer R.
Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature.
Pigment Cell Res. 19:290-302(2006)

PubMed=18632627; DOI=10.1158/0008-5472.CAN-08-0235
Smalley K.S.M., Contractor R., Nguyen T.K., Xiao M., Edwards R., Muthusamy V., King A.J., Flaherty K.T., Bosenberg M.W., Herlyn M., Nathanson K.L.
Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression.
Cancer Res. 68:5743-5752(2008)

PubMed=18790768; DOI=10.1158/1535-7163.MCT-08-0431
Smalley K.S.M., Lioni M., Dalla Palma M., Xiao M., Desai B., Egyhazi Brage S., Hansson J., Wu H., King A.J., Van Belle P., Elder D.E., Flaherty K.T., Herlyn M., Nathanson K.L.
Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomas.
Mol. Cancer Ther. 7:2876-2883(2008)

Cross-references
Cell line collections (Providers) Coriell; WC00048 - Discontinued
Rockland; WM983A-01-0001
Cell line databases/resources cancercelllines; CVCL_6808
Cell_Model_Passport; SIDM01396
Encyclopedic resources Wikidata; Q54994345
Gene expression databases GEO; GSM109047
GEO; GSM185208
GEO; GSM185209
GEO; GSM186503
GEO; GSM186504
Polymorphism and mutation databases Cosmic; 686405
Cosmic; 928685
Cosmic; 1155272
Cosmic; 1155565
Cosmic; 1155569
Cosmic; 1303081
Progenetix; CVCL_6808
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number22