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Cellosaurus CCRF-CEM C7 (CVCL_6825)

[Text version]

Cell line name CCRF-CEM C7
Synonyms CCRF/CEM-C7; CEM-C7; CEM C7; CEMC7; CEM clone 7
Accession CVCL_6825
Resource Identification Initiative To cite this cell line use: CCRF-CEM C7 (RRID:CVCL_6825)
Comments Population: Caucasian.
Characteristics: Sensitive to glucocorticoid-mediated lysis.
Doubling time: 24 +- 3 hours (PubMed=6134583).
Derived from sampling site: Peripheral blood. Cell type=T-cell.
Sequence variations
  • Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0207 (CCRF-CEM)
Children:
CVCL_B7AA (CCRF-CEM C7-14 )CVCL_6826 (CCRF-CEM C7A )CVCL_EP75 (CCRF-CEM C7H2 )
Sex of cell Female
Age at sampling 3Y11M
Category Cancer cell line
Publications

PubMed=269011
Norman M.R., Thompson E.B.
Characterization of a glucocorticoid-sensitive human lymphoid cell line.
Cancer Res. 37:3785-3791(1977)

PubMed=6965106; DOI=10.1128/MCB.1.6.512
Harmon J.M., Thompson E.B.
Isolation and characterization of dexamethasone-resistant mutants from human lymphoid cell line CEM-C7.
Mol. Cell. Biol. 1:512-521(1981)

PubMed=6134583
Zawydiwski R., Harmon J.M., Thompson E.B.
Glucocorticoid-resistant human acute lymphoblastic leukemic cell line with functional receptor.
Cancer Res. 43:3865-3873(1983)

PubMed=3871171; DOI=10.1016/0165-4608(85)90219-5
Moore D.E., Weise K., Zawydiwski R., Thompson E.B.
The karyotype of the glucocorticoid-sensitive, lymphoblastic human T-cell line CCRF-CEM shows a unique deleted and inverted chromosome 9.
Cancer Genet. Cytogenet. 14:89-94(1985)

PubMed=7812967
Strasser-Wozak E.M.C., Hattmannstorfer R., Hala M., Hartmann B.L., Fiegl M., Geley S., Kofler R.
Splice site mutation in the glucocorticoid receptor gene causes resistance to glucocorticoid-induced apoptosis in a human acute leukemic cell line.
Cancer Res. 55:348-353(1995)

Cross-references
Cell line databases/resources Lonza; 240
Encyclopedic resources Wikidata; Q54809016
Entry history
Entry creation04-Apr-2012
Last entry update23-Jun-2022
Version number21