ID   CCRF-CEM C7
AC   CVCL_6825
SY   CCRF-CEM-C7; CCRF/CEM-C7; CEM-C7; CEM C7; CEMC7; CEM clone 7
DR   cancercelllines; CVCL_6825
DR   CLS; 300398
DR   Lonza; 240
DR   Wikidata; Q54809016
RX   PubMed=269011;
RX   PubMed=3871171;
RX   PubMed=6134583;
RX   PubMed=6965106;
RX   PubMed=7812967;
CC   Population: Caucasian.
CC   Characteristics: Sensitive to glucocorticoid-mediated lysis.
CC   Doubling time: 24 +- 3 hours (PubMed=6134583).
CC   Sequence variation: Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0207 ! CCRF-CEM
SX   Female
AG   3Y11M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 24
//
RX   PubMed=269011;
RA   Norman M.R., Thompson E.B.;
RT   "Characterization of a glucocorticoid-sensitive human lymphoid cell
RT   line.";
RL   Cancer Res. 37:3785-3791(1977).
//
RX   PubMed=3871171; DOI=10.1016/0165-4608(85)90219-5;
RA   Moore D.E., Weise K., Zawydiwski R., Thompson E.B.;
RT   "The karyotype of the glucocorticoid-sensitive, lymphoblastic human
RT   T-cell line CCRF-CEM shows a unique deleted and inverted chromosome
RT   9.";
RL   Cancer Genet. Cytogenet. 14:89-94(1985).
//
RX   PubMed=6134583;
RA   Zawydiwski R., Harmon J.M., Thompson E.B.;
RT   "Glucocorticoid-resistant human acute lymphoblastic leukemic cell line
RT   with functional receptor.";
RL   Cancer Res. 43:3865-3873(1983).
//
RX   PubMed=6965106; DOI=10.1128/mcb.1.6.512-521.1981;
RA   Harmon J.M., Thompson E.B.;
RT   "Isolation and characterization of dexamethasone-resistant mutants
RT   from human lymphoid cell line CEM-C7.";
RL   Mol. Cell. Biol. 1:512-521(1981).
//
RX   PubMed=7812967;
RA   Strasser-Wozak E.M.C., Hattmannstorfer R., Hala M., Hartmann B.L.,
RA   Fiegl M., Geley S., Kofler R.;
RT   "Splice site mutation in the glucocorticoid receptor gene causes
RT   resistance to glucocorticoid-induced apoptosis in a human acute
RT   leukemic cell line.";
RL   Cancer Res. 55:348-353(1995).
//