ID   NCI-H3255
AC   CVCL_6831
SY   H3255; H-3255; H3255_DA; NCIH3255
DR   EFO; EFO_0003123
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; CRL-2882
DR   BioSample; SAMN03471808
DR   BioSample; SAMN10988059
DR   CCLE; NCIH3255_LUNG
DR   Cell_Model_Passport; SIDM00046
DR   Cosmic; 897734
DR   Cosmic; 903623
DR   Cosmic; 914952
DR   Cosmic; 1028937
DR   Cosmic; 1128245
DR   Cosmic; 1146914
DR   Cosmic; 2647633
DR   Cosmic-CLP; 1247873
DR   DepMap; ACH-000109
DR   DepMap; ACH-002137
DR   GDSC; 1247873
DR   GEO; GSM63349
DR   GEO; GSM253411
DR   GEO; GSM434297
DR   GEO; GSM794371
DR   GEO; GSM827356
DR   GEO; GSM1374743
DR   GEO; GSM1669833
DR   IARC_TP53; 28350
DR   IGRhCellID; H3255_DAGEO
DR   LiGeA; CCLE_545
DR   NCI-DTP; NCI-H3255
DR   PRIDE; PXD001548
DR   PRIDE; PXD002224
DR   PRIDE; PXD002556
DR   Wikidata; Q54908036
RX   PubMed=11030152;
RX   PubMed=12759538;
RX   PubMed=20215515;
RX   PubMed=20679594;
RX   PubMed=22961666;
RX   PubMed=26202522;
RX   PubMed=26361996;
RX   PubMed=26554430;
RX   PubMed=27397505;
RX   PubMed=30894373;
RX   PubMed=31068700;
CC   Part of: Cancer Cell Line Encyclopedia (CCLE) project.
CC   Part of: COSMIC cell lines project.
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: TP53 c.560-1G>A; splice acceptor mutation (CCLE).
CC   Omics: Deep exome analysis.
CC   Omics: Deep membrane proteome analysis.
CC   Omics: Deep proteome analysis.
CC   Omics: Deep RNAseq analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis.
CC   Genome ancestry: African=3.63%; Native American=0%; East Asian, North=2.06%; East Asian, South=0%; South Asian=0%; European, North=59.85%; European, South=34.46% (PubMed=30894373).
CC   Discontinued: ATCC; CRL-2882; true.
CC   Discontinued: DepMap; ACH-002137; true.
ST   Source(s): ATCC; Cosmic-CLP; PubMed=20679594
ST   Amelogenin: X
ST   CSF1PO: 11,14
ST   D13S317: 11,13
ST   D16S539: 8
ST   D5S818: 11,12
ST   D7S820: 10,13
ST   TH01: 6
ST   TPOX: 8,11
ST   vWA: 16
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-07-19; Version: 23
//
RX   PubMed=11030152; DOI=10.1038/sj.onc.1203815;
RA   Modi S., Kubo A., Oie H., Coxon A.B., Rehmatulla A., Kaye F.J.;
RT   "Protein expression of the RB-related gene family and SV40 large T
RT   antigen in mesothelioma and lung cancer.";
RL   Oncogene 19:4632-4639(2000).
//
RX   PubMed=12759538; DOI=10.1159/000070299;
RA   Fujishita T., Loda M., Turner R.E., Gentler M., Kashii T.,
RA   Breathnach O.S., Johnson B.E.;
RT   "Sensitivity of non-small-cell lung cancer cell lines established from
RT   patients treated with prolonged infusions of paclitaxel.";
RL   Oncology 64:399-406(2003).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=20679594; DOI=10.1093/jnci/djq279;
RA   Gazdar A.F., Girard L., Lockwood W.W., Lam W.L., Minna J.D.;
RT   "Lung cancer cell lines as tools for biomedical discovery and
RT   research.";
RL   J. Natl. Cancer Inst. 102:1310-1321(2010).
//
RX   PubMed=22961666; DOI=10.1158/2159-8290.CD-12-0112;
RA   Byers L.A., Wang J., Nilsson M.B., Fujimoto J., Saintigny P.,
RA   Yordy J., Giri U., Peyton M., Fan Y.H., Diao L., Masrorpour F.,
RA   Shen L., Liu W., Duchemann B., Tumula P., Bhardwaj V., Welsh J.,
RA   Weber S., Glisson B.S., Kalhor N., Wistuba I.I., Girard L.,
RA   Lippman S.M., Mills G.B., Coombes K.R., Weinstein J.N., Minna J.D.,
RA   Heymach J.V.;
RT   "Proteomic profiling identifies dysregulated pathways in small cell
RT   lung cancer and novel therapeutic targets including PARP1.";
RL   Cancer Discov. 2:798-811(2012).
//
RX   PubMed=26202522; DOI=10.1021/acs.jproteome.5b00477;
RA   Kitata R.B., Dimayacyac-Esleta B.R., Choong W.-K., Tsai C.-F.,
RA   Lin T.-D., Tsou C.-C., Weng S.-H., Chen Y.-J., Yang P.-C., Arco S.D.,
RA   Nesvizhskii A.I., Sung T.-Y., Chen Y.-J.;
RT   "Mining missing membrane proteins by high-pH reverse-phase stagetip
RT   fractionation and multiple reaction monitoring mass spectrometry.";
RL   J. Proteome Res. 14:3658-3669(2015).
//
RX   PubMed=26361996; DOI=10.1016/j.jprot.2015.09.003;
RA   Grundner-Culemann K., Dybowski J.N., Klammer M., Tebbe A., Schaab C.,
RA   Daub H.;
RT   "Comparative proteome analysis across non-small cell lung cancer cell
RT   lines.";
RL   J. Proteomics 130:1-10(2016).
//
RX   PubMed=26554430; DOI=10.1021/acs.analchem.5b03639;
RA   Dimayacyac-Esleta B.R., Tsai C.-F., Kitata R.B., Lin P.-Y., Choong W.-K.,
RA   Lin T.-D., Wang Y.-T., Weng S.-H., Yang P.-C., Arco S.D., Sung T.-Y.,
RA   Chen Y.-J.;
RT   "Rapid high-pH reverse phase stagetip for sensitive small-scale
RT   membrane proteomic profiling.";
RL   Anal. Chem. 87:12016-12023(2015).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M.,
RA   Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M.,
RA   Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A.,
RA   Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//