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Cellosaurus HCCLM3 (CVCL_6832)

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Cell line name HCCLM3
Synonyms LM3; MHCC-LM3; MHCCLM3
Accession CVCL_6832
Secondary accession CVCL_7679
Resource Identification Initiative To cite this cell line use: HCCLM3 (RRID:CVCL_6832)
Comments Population: Chinese.
Characteristics: Established from pulmonary metastatic lesions produced in nude mice be subcutaneous inoculation of parent cell line (PubMed=12133480).
Doubling time: 34.9 hours (PubMed=12133480).
Karyotypic information: Has lost chromosome Y.
Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV).
Omics: Transcriptome analysis.
Sequence variations BRD7 p.Glu277Glyfs*18 (c.830_831delAG) (from parent cell line).
KEAP1 p.Pro445Glnfs*13 (c.1334delC) (from parent cell line).
TP53 p.Glu51Ter (c.151G>T) (from parent cell line).
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4972 (MHCC97-H)
Children:
CVCL_WJ13 (HCCLM3-GFP-LC3)
Sex of cell Male
Age at sampling 39Y
Category Cancer cell line
Web pages http://www.cellresource.cn/fdetail.aspx?id=662
http://www.cellresource.cn/fdetail.aspx?id=1967
Publications

PubMed=12133480
Li Y., Tang Z.-Y., Ye S.-L., Liu Y.-K., Chen J., Xue Q., Huang X.-W., Chen J., Bao W.-H., Yang J., Gao D.-M.
Establishment of human hepatocellular carcinoma cell line with spontaneous pulmonary metastasis through in vivo selection.
Zhonghua Yi Xue Za Zhi 82:601-605(2002)

PubMed=12618900; DOI=10.1007/s00432-002-0396-4
Li Y., Tang Y., Ye L., Liu B., Liu K., Chen J., Xue Q.
Establishment of a hepatocellular carcinoma cell line with unique metastatic characteristics through in vivo selection and screening for metastasis-related genes through cDNA microarray.
J. Cancer Res. Clin. Oncol. 129:43-51(2003)

PubMed=15796966; DOI=10.1016/j.cancergencyto.2004.05.010
Yang J., Qin L.-X., Li Y., Ye S.-L., Liu Y.-K., Gao D.-M., Chen J., Tang Z.-Y.
Molecular cytogenetic characteristics of the human hepatocellular carcinoma cell line HCCLM3 with high metastatic potential: comparative genomic hybridization and multiplex fluorescence in situ hybridization.
Cancer Genet. Cytogenet. 158:180-183(2005)

PubMed=19335983
Zheng D., Liu B.-B., Liu Y.-K., Kang X.-N., Sun L., Guo K., Sun R.-X., Chen J., Zhao Y.
Analysis of the expression of Slit/Robo genes and the methylation status of their promoters in the hepatocellular carcinoma cell lines.
Zhonghua Gan Zang Bing Za Zhi 17:198-202(2009)

Cross-references
Cell line collections CCTCC; GDC0289
Cell line databases/resources CCRID; 3131C0001000700094
CCRID; 3142C0001000000316
Ontologies BTO; BTO:0004469
BTO; BTO:0006143
Gene expression databases GEO; GSM1374515
Other Wikidata; Q54881837
Proteomic databases PRIDE; PXD000529
Entry history
Entry creation04-Apr-2012
Last entry update02-Jul-2020
Version number13