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Cellosaurus HCCLM3 (CVCL_6832)

[Text version]

Cell line name HCCLM3
Synonyms HCCLM-3; LM3; MHCC-LM3; MHCCLM3
Accession CVCL_6832
Secondary accession CVCL_7679
Resource Identification Initiative To cite this cell line use: HCCLM3 (RRID:CVCL_6832)
Comments Population: Chinese.
Characteristics: Established from pulmonary metastatic lesions produced in nude mice by 3 rounds of subcutaneous inoculation of parent cell line (PubMed=12133480).
Doubling time: 34.9 hours (PubMed=12133480).
Karyotypic information: Has lost chromosome Y.
Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV).
Omics: Transcriptome analysis.
Sequence variations Mutation; HGNC; 14310; BRD7; Simple; p.Glu277Glyfs*18 (c.830_831delAG); Zygosity=Unspecified (from parent cell line).
Mutation; HGNC; 23177; KEAP1; Simple; p.Pro445Glnfs*13 (c.1334delC); Zygosity=Unspecified (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Glu51Ter (c.151G>T); ClinVar=VCV000568781; Zygosity=Unspecified (from parent cell line).
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4972 (MHCC97-H)
Sex of cell Male
Age at sampling 39Y
Category Cancer cell line

Li Y., Tang Z.-Y., Ye S.-L., Liu Y.-K., Chen J., Xue Q., Huang X.-W., Chen J., Bao W.-H., Yang J., Gao D.-M.
Establishment of human hepatocellular carcinoma cell line with spontaneous pulmonary metastasis through in vivo selection.
Zhonghua Yi Xue Za Zhi 82:601-605(2002)

PubMed=12618900; DOI=10.1007/s00432-002-0396-4
Li Y., Tang Y., Ye L., Liu B., Liu K., Chen J., Xue Q.
Establishment of a hepatocellular carcinoma cell line with unique metastatic characteristics through in vivo selection and screening for metastasis-related genes through cDNA microarray.
J. Cancer Res. Clin. Oncol. 129:43-51(2003)

PubMed=15796966; DOI=10.1016/j.cancergencyto.2004.05.010
Yang J., Qin L.-X., Li Y., Ye S.-L., Liu Y.-K., Gao D.-M., Chen J., Tang Z.-Y.
Molecular cytogenetic characteristics of the human hepatocellular carcinoma cell line HCCLM3 with high metastatic potential: comparative genomic hybridization and multiplex fluorescence in situ hybridization.
Cancer Genet. Cytogenet. 158:180-183(2005)

Zheng D., Liu B.-B., Liu Y.-K., Kang X.-N., Sun L., Guo K., Sun R.-X., Chen J., Zhao Y.
Analysis of the expression of Slit/Robo genes and the methylation status of their promoters in the hepatocellular carcinoma cell lines.
Zhonghua Gan Zang Bing Za Zhi 17:198-202(2009)

PubMed=32884988; DOI=10.1016/j.gendis.2019.12.008
Lin Y.-L., Li Y.
Study on the hepatocellular carcinoma model with metastasis.
Genes Dis. 7:336-350(2020)

Cell line collections CCTCC; GDC0289
Cell line databases/resources CCRID; 4201HUM-CCTCC00289
Ontologies BTO; BTO:0004469
Gene expression databases GEO; GSM1374515
Other Wikidata; Q54881837
Proteomic databases PRIDE; PXD000529
Entry history
Entry creation04-Apr-2012
Last entry update23-Sep-2021
Version number16