ID   HCCLM3
AC   CVCL_6832
AS   CVCL_7679
SY   HCCLM-3; LM3; MHCC-LM3; MHCCLM3
DR   BTO; BTO:0004469
DR   cancercelllines; CVCL_6832
DR   CCRID; 4201HUM-CCTCC00289
DR   CCTCC; GDC0289
DR   ChEMBL-Cells; CHEMBL4513111
DR   GEO; GSM1374515
DR   PRIDE; PXD000529
DR   PRIDE; PXD005291
DR   PubChem_Cell_line; CVCL_6832
DR   Wikidata; Q54881837
RX   PubMed=12133480;
RX   PubMed=12618900;
RX   PubMed=15796966;
RX   PubMed=19335983;
RX   PubMed=32884988;
CC   Population: Chinese.
CC   Characteristics: Established from pulmonary metastatic lesions produced in nude mice by 3 rounds of subcutaneous inoculation of parent cell line (PubMed=12133480).
CC   Doubling time: 34.9 hours (PubMed=12133480).
CC   Karyotypic information: Has lost chromosome Y.
CC   Sequence variation: Mutation; HGNC; 14310; BRD7; Simple; p.Glu277Glyfs*18 (c.830_831delAG); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 23177; KEAP1; Simple; p.Pro445Glnfs*13 (c.1334delC); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Glu51Ter (c.151G>T); ClinVar=VCV000568781; Zygosity=Unspecified (from parent cell line).
CC   Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV).
CC   Omics: Transcriptome analysis by microarray.
DI   NCIt; C7956; Adult hepatocellular carcinoma
DI   ORDO; Orphanet_210159; Adult hepatocellular carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_4972 ! MHCC97-H
SX   Male
AG   39Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 19
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RX   PubMed=12133480;
RA   Li Y., Tang Z.-Y., Ye S.-L., Liu Y.-K., Chen J., Xue Q., Huang X.-W.,
RA   Chen J., Bao W.-H., Yang J., Gao D.-M.;
RT   "Establishment of human hepatocellular carcinoma cell line with
RT   spontaneous pulmonary metastasis through in vivo selection.";
RL   Zhonghua Yi Xue Za Zhi 82:601-605(2002).
//
RX   PubMed=12618900; DOI=10.1007/s00432-002-0396-4;
RA   Li Y., Tang Y., Ye L., Liu B., Liu K., Chen J., Xue Q.;
RT   "Establishment of a hepatocellular carcinoma cell line with unique
RT   metastatic characteristics through in vivo selection and screening for
RT   metastasis-related genes through cDNA microarray.";
RL   J. Cancer Res. Clin. Oncol. 129:43-51(2003).
//
RX   PubMed=15796966; DOI=10.1016/j.cancergencyto.2004.05.010;
RA   Yang J., Qin L.-X., Li Y., Ye S.-L., Liu Y.-K., Gao D.-M., Chen J.,
RA   Tang Z.-Y.;
RT   "Molecular cytogenetic characteristics of the human hepatocellular
RT   carcinoma cell line HCCLM3 with high metastatic potential: comparative
RT   genomic hybridization and multiplex fluorescence in situ
RT   hybridization.";
RL   Cancer Genet. Cytogenet. 158:180-183(2005).
//
RX   PubMed=19335983; DOI=10.3760/cma.j.issn.1007-3418.2009.03.010;
RA   Zheng D., Liu B.-B., Liu Y.-K., Kang X.-N., Sun L., Guo K., Sun R.-X.,
RA   Chen J., Zhao Y.;
RT   "Analysis of the expression of Slit/Robo genes and the methylation
RT   status of their promoters in the hepatocellular carcinoma cell
RT   lines.";
RL   Zhonghua Gan Zang Bing Za Zhi 17:198-202(2009).
//
RX   PubMed=32884988; DOI=10.1016/j.gendis.2019.12.008;
RA   Lin Y.-L., Li Y.;
RT   "Study on the hepatocellular carcinoma model with metastasis.";
RL   Genes Dis. 7:336-350(2020).
//