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Cellosaurus Lu-130 (CVCL_6862)

[Text version]

Cell line name Lu-130
Synonyms NCC-c-Lu-130; LU-130; Lu130
Accession CVCL_6862
Resource Identification Initiative To cite this cell line use: Lu-130 (RRID:CVCL_6862)
Comments Problematic cell line: Contaminated. Shown to be a Lu-134-A (or Lu-134-B) derivative (PubMed=16643607; PubMed=20143388). Originally thought to originate from a 61 year old male patient with small cell lung carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00232.
Omics: Transcriptome analysis.
Sequence variations TP53 p.Pro278Leu (c.833C>T) (PubMed=1312700).
Disease Small cell lung carcinoma (NCIt: C4917)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1387 (Lu-134-A)
Sex of cell Male
Age at sampling 80Y
Category Cancer cell line
Web pages http://cell.brc.riken.jp/ja/quality/str/origin/confirm_report/confirm_table4

Terasaki T., Shimosato Y., Nakajima T., Tsumuraya M., Morinaga S., Hirohashi S., Yamaguchi K., Kato K., Ichinose H., Nagatsu T.
Changes in cell characteristics due to culture conditions in cell lines from human small cell lung cancer.
Jpn. J. Clin. Oncol. 16:203-212(1986)

Sameshima Y., Matsuno Y., Hirohashi S., Shimosato Y., Mizoguchi H., Sugimura T., Terada M., Yokota J.
Alterations of the p53 gene are common and critical events for the maintenance of malignant phenotypes in small-cell lung carcinoma.
Oncogene 7:451-457(1992)

PubMed=12107105; DOI=10.1016/S0002-9440(10)64172-7
Yokoi S., Yasui K., Saito-Ohara F., Koshikawa K., Iizasa T., Fujisawa T., Terasaki T., Horii A., Takahashi T., Hirohashi S., Inazawa J.
A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers.
Am. J. Pathol. 161:207-216(2002)

PubMed=15016488; DOI=10.1016/S0140-6736(04)15693-6
Jones M.H., Virtanen C., Honjoh D., Miyoshi T., Satoh Y., Okumura S., Nakagawa K., Nomura H., Ishikawa Y.
Two prognostically significant subtypes of high-grade lung neuroendocrine tumours independent of small-cell and large-cell neuroendocrine carcinomas identified by gene expression profiles.
Lancet 363:775-781(2004)

PubMed=16643607; DOI=10.1111/j.1749-0774.2005.00007.x
Yoshino K., Iimura E., Saijo K., Iwase S., Fukami K., Ohno T., Obata Y., Nakamura Y.
Essential role for gene profiling analysis in the authentication of human cell lines.
Hum. Cell 19:43-48(2006)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cell line collections RCB; RCB0465 - Discontinued
Cell line databases/resources CGH-DB; 89-1
CGH-DB; 9058-4
Ontologies EFO; EFO_0003142
Biological sample resources BioSample; SAMN03151826
Gene expression databases GEO; GSM17309
Other Wikidata; Q54903190
Polymorphism and mutation databases Cosmic; 809118
Cosmic; 844807
Cosmic; 918004
Cosmic; 1212192
Cosmic; 1571748
Cosmic; 2668337
IARC_TP53; 1013
Entry history
Entry creation04-Apr-2012
Last entry updated25-Feb-2019
Version number17