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Cellosaurus 6T-CEM (CVCL_6869)

[Text version]

Cell line name 6T-CEM
Synonyms 6-T CEM
Accession CVCL_6869
Resource Identification Initiative To cite this cell line use: 6T-CEM (RRID:CVCL_6869)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8296.
Selected for resistance to: ChEBI; CHEBI:9555; Tioguanine (6-thioguanine; 6-TG).
Derived from sampling site: Peripheral blood.
Sequence variations Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0207 (CCRF-CEM)
Children:
CVCL_U293 (6T-CEM20)
Sex of cell Female
Age at sampling 3Y11M
Category Cancer cell line
STR profile Source(s): ATCC; CCRID

Markers:
AmelogeninX
CSF1PO10,11
D2S133824
D3S135814,15
D5S81811,12,13 (ATCC)
11,13 (CCRID)
D7S8209,14
D8S117913
D13S31711,12
D16S53910,13
D18S5113,18
D19S43314,15
D21S1131,33.2
FGA23,24
TH016,7
TPOX8
vWA17,19

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Publications

Patent=US4705687
Lau C.Y.
Treatment of autoimmune diseases such as rheumatoid arthritis with suppressor factor.
Patent number US4705687, 10-Nov-1987

Patent=US4728614
Lau C.Y.
Mutant human T cell line producing immunosuppressive factor and method for obtaining such mutants.
Patent number US4728614, 01-Mar-1988

Cross-references
Cell line collections ATCC; CRL-8296
Cell line databases/resources CCRID; 3101HUMTCHu2
Biological sample resources BioSample; SAMN03471201
Other Wikidata; Q54604612
Entry history
Entry creation04-Apr-2012
Last entry update23-Sep-2021
Version number23