ID   6T-CEM
AC   CVCL_6869
SY   6-T CEM
DR   ATCC; CRL-8296
DR   BioSample; SAMN03471201
DR   cancercelllines; CVCL_6869
DR   CCRID; 3101HUMTCHu2
DR   CLS; 305132
DR   Wikidata; Q54604612
RX   Patent=US4705687;
RX   Patent=US4728614;
CC   Group: Patented cell line.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8296.
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:9555; Tioguanine (6-thioguanine; 6-TG).
CC   Sequence variation: Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
ST   Source(s): ATCC; CCRID
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 11,12
ST   D16S539: 10,13
ST   D18S51: 13,18
ST   D19S433: 14,15
ST   D21S11: 31,33.2
ST   D2S1338: 24
ST   D3S1358: 14,15
ST   D5S818: 11,12,13 (ATCC)
ST   D5S818: 11,13 (CCRID)
ST   D7S820: 9,14
ST   D8S1179: 13
ST   FGA: 23,24
ST   TH01: 6,7
ST   TPOX: 8
ST   vWA: 17,19
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0207 ! CCRF-CEM
SX   Female
AG   3Y11M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 28
//
RX   Patent=US4705687;
RA   Lau C.Y.;
RT   "Treatment of autoimmune diseases such as rheumatoid arthritis with
RT   suppressor factor.";
RL   Patent number US4705687, 10-Nov-1987.
//
RX   Patent=US4728614;
RA   Lau C.Y.;
RT   "Mutant human T cell line producing immunosuppressive factor and
RT   method for obtaining such mutants.";
RL   Patent number US4728614, 01-Mar-1988.
//