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Cellosaurus ACCS (CVCL_6876)

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Cell line name ACCS
Synonyms ACC-S
Accession CVCL_6876
Resource Identification Initiative To cite this cell line use: ACCS (RRID:CVCL_6876)
Comments Problematic cell line: Contaminated. Shown to be a T24 derivative (PubMed=19557180; PubMed=20143388). Originally thought to originate from a 56 year old female patient with salivary gland adenoid cystic carcinoma.
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00361.
Omics: Deep exome analysis.
Sequence variations Homozygous for HRAS p.Gly12Val (c.35G>T) (from parent cell line).
TERT c.228C>T (-124C>T); in promoter (from parent cell line).
Homozygous for TP53 p.Tyr126Ter (c.378C>G) (CCLE).
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0554 (T24)
Sex of cell Female
Age at sampling 82Y
Category Cancer cell line
Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations_v9_distribution.xlsx
Publications

PubMed=2162254
Shirasuna K., Watatani K., Furusawa H., Saka M., Morioka S., Yoshioka H., Matsuya T.
Biological characterization of pseudocyst-forming cell lines from human adenoid cystic carcinomas of minor salivary gland origin.
Cancer Res. 50:4139-4145(1990)

DOI=10.1007/0-306-46872-7_9
Sato M.
Salivary gland tumors.
(In) Human cell culture. Vol. 1. Cancer Cell Lines part 1; Masters J.R.W., Palsson B.O. (eds.); pp.161-178; Kluwer Academic Publishers; New York (1999)

PubMed=19557180; DOI=10.1371/journal.pone.0006040
Phuchareon J., Ohta Y., Woo J.M., Eisele D.W., Tetsu O.
Genetic profiling reveals cross-contamination and misidentification of 6 adenoid cystic carcinoma cell lines: ACC2, ACC3, ACCM, ACCNS, ACCS and CAC2.
PLoS ONE 4:E6040-E6040(2009)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

DOI=10.4103/2468-5585.200513
Liu N.-N., Zhang S.-L., Chen W.
The cross-contaminated cell lines of adenoid cystic carcinoma: a crucial concern.
Transl. Surg. 2:10-13(2017)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line databases/resources CCLE; ACCS_URINARY_TRACT
Cell_Model_Passport; SIDM01166
DepMap; ACH-001011
Biological sample resources BioSample; SAMN03151936
BioSample; SAMN10989595
Chemistry resources PharmacoDB; ACCS_53_2019
Other Wikidata; Q54608335
Polymorphism and mutation databases IARC_TP53; 28390
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number19