Cellosaurus OCM-8 (CVCL_6938)

Cell line name OCM-8
Synonyms OCM8; Ocm8; ocm-8
Accession CVCL_6938
Resource Identification Initiative To cite this cell line use: OCM-8 (RRID:CVCL_6938)
Comments Problematic cell line: Contaminated. Shown to be a SK-MEL-28 derivative (PubMed=22236444 and STR profile from PubMed=18689700). Was originally thought to originate from an uveal melanoma.
From: Kan-Mitchell J.; Wayne State University; Detroit; USA.
Sequence variation: Homozygous for BRAF p.Val600Glu (from parent cell line).
Sequence variation: Heterozygous for CDK4 p.Arg24Cys (from parent cell line).
Sequence variation: Homozygous for EGFR p.Pro753Ser (from parent cell line).
Sequence variation: Homozygous for TP53 p.Leu145Arg (from parent cell line).
Disease Cutaneous melanoma (NCIt: C3510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0526 (SK-MEL-28)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): ESTDAB; PubMed=18689700

Markers:
AmelogeninX,Y
CSF1PO10,12
D13S31711,12
D16S5399,12
D18S5112,16
D21S1128,29
D3S135816,18
D5S81811,13
D7S82010
D8S117913
FGA19
TH017
TPOX8,12
vWA16,19
Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations-v8_0.pdf
Publications

PubMed=16772116; DOI=10.1016/j.cancergencyto.2005.11.016
White J.S., Becker R.L., McLean I.W., Director-Myska A.E., Nath J.
Molecular cytogenetic evaluation of 10 uveal melanoma cell lines.
Cancer Genet. Cytogenet. 168:11-21(2006)

PubMed=18689700; DOI=10.1167/iovs.08-2324
Folberg R., Kadkol S.S., Frenkel S., Valyi-Nagy K., Jager M.J., Pe'er J., Maniotis A.J.
Authenticating cell lines in ophthalmic research laboratories.
Invest. Ophthalmol. Vis. Sci. 49:4697-4701(2008)

PubMed=22236444; DOI=10.1111/j.1755-148X.2012.00971.x
Griewank K.G., Yu X., Khalili J., Sozen M.M., Stempke-Hale K., Bernatchez C., Wardell S., Bastian B.C., Woodman S.E.
Genetic and molecular characterization of uveal melanoma cell lines.
Pigment Cell Melanoma Res. 25:182-187(2012)

Cross-references
Cell line databases/resources ESTDAB; ESTDAB-130
Biological sample resources BioSample; SAMN06481120
Polymorphism and mutation databases Cosmic; 1320370
Cosmic; 1628410