Cellosaurus OCM-8 (CVCL_6938)

Cell line name OCM-8
Synonyms OCM8; Ocm8; ocm-8
Accession CVCL_6938
Resource Identification Initiative To cite this cell line use: OCM-8 (RRID:CVCL_6938)
Comments Problematic cell line: Contaminated. Shown to be a SK-MEL-28 derivative (PubMed=22236444 and STR profile from PubMed=18689700). Was originally thought to originate from an uveal melanoma.
From: Kan-Mitchell J.; Wayne State University; Detroit; USA.
Sequence variations Homozygous for BRAF p.Val600Glu (c.1799T>A) (from parent cell line).
Heterozygous for CDK4 p.Arg24Cys (from parent cell line).
Homozygous for EGFR p.Pro753Ser (from parent cell line).
PTEN p.Thr167Ala (from parent cell line).
Homozygous for TP53 p.Leu145Arg (from parent cell line).
Disease Cutaneous melanoma (NCIt: C3510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0526 (SK-MEL-28)
Sex of cell Male
Age at sampling 51Y
Category Cancer cell line
STR profile Source(s): ESTDAB; PubMed=18689700

Markers:
AmelogeninX,Y
CSF1PO10,12
D13S31711,12
D16S5399,12
D18S5112,16
D21S1128,29
D3S135816,18
D5S81811,13
D7S82010
D8S117913
FGA19
TH017
TPOX8,12
vWA16,19
Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations-v8_0.pdf
Publications

PubMed=16772116; DOI=10.1016/j.cancergencyto.2005.11.016
White J.S., Becker R.L., McLean I.W., Director-Myska A.E., Nath J.
Molecular cytogenetic evaluation of 10 uveal melanoma cell lines.
Cancer Genet. Cytogenet. 168:11-21(2006)

PubMed=18689700; DOI=10.1167/iovs.08-2324
Folberg R., Kadkol S.S., Frenkel S., Valyi-Nagy K., Jager M.J., Pe'er J., Maniotis A.J.
Authenticating cell lines in ophthalmic research laboratories.
Invest. Ophthalmol. Vis. Sci. 49:4697-4701(2008)

PubMed=22236444; DOI=10.1111/j.1755-148X.2012.00971.x
Griewank K.G., Yu X., Khalili J., Sozen M.M., Stempke-Hale K., Bernatchez C., Wardell S., Bastian B.C., Woodman S.E.
Genetic and molecular characterization of uveal melanoma cell lines.
Pigment Cell Melanoma Res. 25:182-187(2012)

Cross-references
Cell line databases/resources ESTDAB; ESTDAB-130
Biological sample resources BioSample; SAMN06481120
Polymorphism and mutation databases Cosmic; 1320370
Cosmic; 1628410