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Cellosaurus SPC-A1 (CVCL_6955)

[Text version]
Cell line name SPC-A1
Synonyms SPC-A-1; SPCA-1; SPCA1
Accession CVCL_6955
Resource Identification Initiative To cite this cell line use: SPC-A1 (RRID:CVCL_6955)
Comments Problematic cell line: Contaminated. Shown to be a HeLa derivative (CCRID; PubMed=26116706). Originally thought to be a lung adenocarcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00608.
Population: African American.
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Miscellaneous: Formerly the CCRID database had 3 entries describing this cell line (3111C0001CCC000387, 3131C0001000700053, 3142C0001000000050). They were one of the sources for the STR profile of this entry.
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related cervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0030 (HeLa)
Children:
CVCL_YP05 (SPC-A-1BM)CVCL_W217 (SPC-A1/DTX)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
STR profile Source(s): CCRID; PubMed=26116706

Markers:
AmelogeninX
CSF1PO9,10
D2S133817
D3S135815,18
D5S81811,12
D6S104318,19
D7S8208,12
D8S117912
D12S39120,25
D13S31712,13.3
D16S5399,10
D18S5116
D19S43313,14
D21S1127,28
FGA21
Penta D8,15
Penta E7,17
TH017
TPOX8,12
vWA16,18

Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
Publications

PubMed=22862169; DOI=10.4149/neo_2012_087
Zhou C.H., Yang S.F., Li P.Q.
Human lung cancer cell line SPC-A1 contains cells with characteristics of cancer stem cells.
Neoplasma 59:685-692(2012)

PubMed=26116706; DOI=10.1096/fj.14-266718
Ye F., Chen C.-G., Qin J., Liu J., Zheng C.-Y.
Genetic profiling reveals an alarming rate of cross-contamination among human cell lines used in China.
FASEB J. 29:4268-4272(2015)

Cross-references
Cell line collections (Providers) CCTCC; GDC0050
Cell line databases/resources TOKU-E; 3573
Anatomy/cell type resources BTO; BTO:0006512
Encyclopedic resources Wikidata; Q54955522
Polymorphism and mutation databases Cosmic; 1515871
Cosmic; 2664119
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number15