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Cellosaurus MDA-686Ln (CVCL_6984)

[Text version]
Cell line name MDA-686Ln
Synonyms MDA 686Ln; MDA686Ln; MDA686LN; MDA 686LN; MDA 686-LN; MDA 686 Ln; 686LN; 686Ln
Accession CVCL_6984
Resource Identification Initiative To cite this cell line use: MDA-686Ln (RRID:CVCL_6984)
Comments Problematic cell line: Partially contaminated. Some stocks are contaminated by UM-SCC-1 (PubMed=21868764).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00442.
Omics: Deep exome analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Pro151Ser (c.451C>T); ClinVar=VCV000012370; Zygosity=Unspecified (PubMed=7927946).
Disease Oropharyngeal squamous cell carcinoma (NCIt: C8181)
Squamous cell carcinoma of the oropharynx (ORDO: Orphanet_500478)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_D099 (686LN-M3e)CVCL_D097 (686LN-M4e)CVCL_D098 (686LN-R30)
Originate from same individual CVCL_6983 ! MDA-686
CVCL_6985 ! MDA-686Tu
Sex of cell Male
Age at sampling 48Y
Category Cancer cell line
STR profile Source(s): PubMed=21868764

Markers:
AmelogeninX
CSF1PO12
D5S81812
D7S82010
D13S31712
D16S5398,9
TH017,8
TPOX10,11
vWA15,16

Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
Publications

PubMed=7927946; DOI=10.1002/ijc.2910590316
Xu L., Davidson B.J., Murty V.V.V.S., Li R.-G., Sacks P.G., Garin-Chesa P., Schantz S.P., Chaganti R.S.K.
TP53 gene mutations and CCND1 gene amplification in head and neck squamous cell carcinoma cell lines.
Int. J. Cancer 59:383-387(1994)

PubMed=14724901; DOI=10.1002/hed.10344
Wreesmann V.B., Wang D., Goberdhan A., Prasad M., Ngai I., Schnaser E.A., Sacks P.G., Singh B.
Genetic abnormalities associated with nodal metastasis in head and neck cancer.
Head Neck 26:10-15(2004)

PubMed=15641986; DOI=10.1111/j.1600-0714.2004.00258.x
Vigneswaran N., Wu J., Sacks P.G., Gilcrease M., Zacharias W.
Microarray gene expression profiling of cell lines from primary and metastatic tongue squamous cell carcinoma: possible insights from emerging technology.
J. Oral Pathol. Med. 34:77-86(2005)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690
Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C., Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G., Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=26754630; DOI=10.1186/s13046-016-0284-4
Hyakusoku H., Sano D., Takahashi H., Hatano T., Isono Y., Shimada S., Ito Y., Myers J.N., Oridate N.
JunB promotes cell invasion, migration and distant metastasis of head and neck squamous cell carcinoma.
J. Exp. Clin. Cancer Res. 35:6.1-6.12(2016)

PubMed=29156801; DOI=10.18632/oncotarget.21174
Kalu N.N., Mazumdar T., Peng S.-H., Shen L., Sambandam V., Rao X.-Y., Xi Y.-X., Li L.-R., Qi Y., Gleber-Netto F.O., Patel A., Wang J., Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_6984
Anatomy/cell type resources BTO; BTO:0003052
Encyclopedic resources Wikidata; Q54904562
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number24