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Cellosaurus LoVo/DR5 (CVCL_6C49)

Cell line name LoVo/DR5
Accession CVCL_6C49
Resource Identification Initiative To cite this cell line use: LoVo/DR5 (RRID:CVCL_6C49)
Comments Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Sequence variations Homozygous for ACVR2A p.Lys437fs*5 (c.1310delA) (from parent cell line).
APC p.Arg1114Ter (c.3340C>T), p.Met1431fs*42 (c.4289delC) and p.Arg2816Gln (c.8447G>A) (from parent cell line).
KRAS p.Gly13Asp (c.38G>A) (from parent cell line).
SMAD2 p.Ala292Val (c.875C>T) (from parent cell line).
Homozygous for TGFBR2 p.Lys128Serfs*35 (c.383delA) (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Derived from metastatic site: Left supraclavicular lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0399 (LoVo)
Sex of cell Male
Age at sampling 56Y
Category Cancer cell line

Slovak M.L., Hoeltge G.A., Dalton W.S., Trent J.M.
Pharmacological and biological evidence for differing mechanisms of doxorubicin resistance in two human tumor cell lines.
Cancer Res. 48:2793-2797(1988)

Slovak M.L., Coccia M., Meltzer P.S., Trent J.M.
Molecular analysis of two human doxorubicin-resistant cell lines: evidence for differing multidrug resistance mechanisms.
Anticancer Res. 11:423-428(1991)

Other Wikidata; Q54902904