ID   HPLA-A3
AC   CVCL_6G77
DR   cancercelllines; CVCL_6G77
DR   Wikidata; Q54890298
RX   PubMed=22687401;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Transfected with: HGNC; 7968; NR1I2.
CC   Transfected with: UniProtKB; P08659; Firefly luciferase.
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
DI   NCIt; C3728; Hepatoblastoma
DI   ORDO; Orphanet_449; Hepatoblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0027 ! Hep-G2
SX   Male
AG   15Y
CA   Cancer cell line
DT   Created: 23-02-16; Last updated: 05-10-23; Version: 14
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RX   PubMed=22687401; DOI=10.1248/bpb.35.677;
RA   Sekimoto M., Sano S., Hosaka T., Nemoto K., Degawa M.;
RT   "Establishment of a stable human cell line, HPL-A3, for use in
RT   reporter gene assays of cytochrome P450 3A inducers.";
RL   Biol. Pharm. Bull. 35:677-685(2012).
//