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Cellosaurus BLM (CVCL_7035)

[Text version]
Cell line name BLM
Synonyms BRO Lung Metastasis
Accession CVCL_7035
Resource Identification Initiative To cite this cell line use: BLM (RRID:CVCL_7035)
Comments Population: Caucasian.
Characteristics: Obtained by injection of parent cell line in nude mice and selection of cells from lung metastases.
Omics: Transcriptome analysis by RNAseq.
Misspelling: BML; Cosmic=1132580.
Derived from site: In situ; Shoulder, skin; UBERON=UBERON_0001483.
Sequence variations
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Arg (c.182A>G); ClinVar=VCV000013900; Zygosity=Unspecified (PubMed=25728708).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_7036 (BRO)
Sex of cell Male
Age at sampling 34Y
Category Cancer cell line
Publications

PubMed=1918136; DOI=10.1083/jcb.115.1.191
Quax P.H.A., van Muijen G.N.P., Weening-Verhoeff E.J.D., Lund L.R., Dano K., Ruiter D.J., Verheijen J.H.
Metastatic behavior of human melanoma cell lines in nude mice correlates with urokinase-type plasminogen activator, its type-1 inhibitor, and urokinase-mediated matrix degradation.
J. Cell Biol. 115:191-199(1991)

PubMed=2060184; DOI=10.1007/BF01753729
van Muijen G.N.P., Cornelissen I.L.M.H.A., Jansen K.F.J., Figdor C.G., Johnson J.P., Brocker E.-B., Ruiter D.J.
Antigen expression of metastasizing and non-metastasizing human melanoma cells xenografted into nude mice.
Clin. Exp. Metastasis 9:259-272(1991)

PubMed=25502142; DOI=10.1038/ncomms6712
Muller J., Krijgsman O., Tsoi J., Robert L., Hugo W., Song C., Kong X.-J., Possik P.A., Cornelissen-Steijger P.D.M., Geukes Foppen M.H., Kemper K., Goding C.R., McDermott U., Blank C., Haanen J.B.A.G., Graeber T.G., Ribas A., Lo R.S., Peeper D.S.
Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma.
Nat. Commun. 5:5712.1-5712.15(2014)

PubMed=25728708; DOI=10.1111/pcmr.12364
Vogel C.J., Smit M.A., Maddalo G., Possik P.A., Sparidans R.W., van der Burg S.H., Verdegaal E.M.E., Heck A.J.R., Samatar A.A., Beijnen J.H., Altelaar A.F.M., Peeper D.S.
Cooperative induction of apoptosis in NRAS mutant melanoma by inhibition of MEK and ROCK.
Pigment Cell Melanoma Res. 28:307-317(2015)

PubMed=26550137
Leder D.C., Brown J.R., Ramaraj P.
In-vitro rescue and recovery studies of human melanoma (BLM) cell growth, adhesion and migration functions after treatment with progesterone.
Int. J. Clin. Exp. Med. 8:12275-12285(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_7035
Anatomy/cell type resources BTO; BTO:0002803
Encyclopedic resources Wikidata; Q54797375
Gene expression databases GEO; GSM1507940
Polymorphism and mutation databases Cosmic; 808558
Cosmic; 1132580
Cosmic; 1181767
Cosmic; 2036700
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number14