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Cellosaurus GIST882 (CVCL_7044)

[Text version]

Cell line name GIST882
Synonyms GIST-882; GIST 882
Accession CVCL_7044
Resource Identification Initiative To cite this cell line use: GIST882 (RRID:CVCL_7044)
Comments Omics: Deep RNAseq analysis.
Omics: H3K27ac ChIP-seq epigenome analysis.
Sequence variations Mutation; HGNC; 6342; KIT; Simple; p.Lys642Glu (c.1924A>G); ClinVar=VCV000013866; Zygosity=Homozygous (PubMed=11526490; PubMed=16077968).
Disease Gastrointestinal stromal tumor (NCIt: C3868)
Gastrointestinal stromal tumor (ORDO: Orphanet_44890)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_A9N2 (GIST882IMR)
Category Cancer cell line
Publications

PubMed=11526490; DOI=10.1038/sj.onc.1204704
Tuveson D.A., Willis N.A., Jacks T., Griffin J.D., Singer S., Fletcher C.D.M., Fletcher J.A., Demetri G.D.
STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications.
Oncogene 20:5054-5058(2001)

PubMed=16077968; DOI=10.3892/or.14.3.645
Noma K., Naomoto Y., Gunduz M., Matsuoka J., Yamatsuji T., Shirakawa Y., Nobuhisa T., Okawa T., Takaoka M., Tomono Y., Hiroyuki O., Gunduz E., Tanaka N.
Effects of imatinib vary with the types of KIT-mutation in gastrointestinal stromal tumor cell lines.
Oncol. Rep. 14:645-650(2005)

PubMed=16982758; DOI=10.1158/0008-5472.CAN-06-0165
Bauer S., Yu L.K., Demetri G.D., Fletcher J.A.
Heat shock protein 90 inhibition in imatinib-resistant gastrointestinal stromal tumor.
Cancer Res. 66:9153-9161(2006)

PubMed=19706776; DOI=10.1158/0008-5472.CAN-08-4004
Muhlenberg T., Zhang Y., Wagner A.J., Grabellus F., Bradner J., Taeger G., Lang H., Taguchi T., Schuler M., Fletcher J.A., Bauer S.
Inhibitors of deacetylases suppress oncogenic KIT signaling, acetylate HSP90, and induce apoptosis in gastrointestinal stromal tumors.
Cancer Res. 69:6941-6950(2009)

PubMed=25239608; DOI=10.1158/1078-0432.CCR-14-1397
Garner A.P., Gozgit J.M., Anjum R., Vodala S., Schrock A., Zhou T., Serrano C., Eilers G., Zhu M., Ketzer J., Wardwell S., Ning Y., Song Y., Kohlmann A., Wang F., Clackson T., Heinrich M.C., Fletcher J.A., Bauer S., Rivera V.M.
Ponatinib inhibits polyclonal drug-resistant KIT oncoproteins and shows therapeutic potential in heavily pretreated gastrointestinal stromal tumor (GIST) patients.
Clin. Cancer Res. 20:5745-5755(2014)

PubMed=29866822; DOI=10.1073/pnas.1802079115
Hemming M.L., Lawlor M.A., Zeid R., Lesluyes T., Fletcher J.A., Raut C.P., Sicinska E.T., Chibon F., Armstrong S.A., Demetri G.D., Bradner J.E.
Gastrointestinal stromal tumor enhancers support a transcription factor network predictive of clinical outcome.
Proc. Natl. Acad. Sci. U.S.A. 115:E5746-E5755(2018)

PubMed=30488756; DOI=10.1080/15384101.2018.1553335
Tu Y.-Q., Zuo R., Ni N., Eilers G., Wu D.-L., Pei Y.-T., Nie Z.-M., Wu Y.-Q., Wu Y.-H., Ou W.-B.
Activated tyrosine kinases in gastrointestinal stromal tumor with loss of KIT oncoprotein expression.
Cell Cycle 17:2577-2592(2018)

Cross-references
Cell line databases/resources Lonza; 694
Gene expression databases GEO; GSM486234
GEO; GSM2527254
GEO; GSM2527255
GEO; GSM2786738
Other Wikidata; Q54835862
Polymorphism and mutation databases Cosmic; 1180672
Cosmic; 1217560
Cosmic; 1244759
Cosmic; 1477623
Cosmic; 1873949
Cosmic; 2805389
Progenetix; CVCL_7044
Entry history
Entry creation04-Apr-2012
Last entry update20-May-2021
Version number13