Cellosaurus cell line Ma-1 (CVCL_7059)

• Mutation; HGNC; 3236; EGFR; Simple; p.Glu746_Ala750del; Zygosity=Unspecified (PubMed=17332333).
  
• Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Unspecified (PubMed=10536175).
  

PubMed=1650680; DOI=10.1378/chest.100.2.429
Masuda N., Fukuoka M., Takada M., Kudoh S., Kusunoki Y.
Establishment and characterization of 20 human non-small cell lung cancer cell lines in a serum-free defined medium (ACL-4).
Chest 100:429-438(1991)

PubMed=9393586; DOI=10.1007/s004320050101
Shimizu E., Zhao M.-R., Shinohara A., Namikawa O., Ogura T., Masuda N., Takada M., Fukuoka M., Sone S.
Differential expressions of cyclin A and the retinoblastoma gene product in histological subtypes of lung cancer cell lines.
J. Cancer Res. Clin. Oncol. 123:533-538(1997)

PubMed=10536175; DOI=10.3892/ijo.15.5.927
Fujita T., Kiyama M., Tomizawa Y., Kohno T., Yokota J.
Comprehensive analysis of p53 gene mutation characteristics in lung carcinoma with special reference to histological subtypes.
Int. J. Oncol. 15:927-934(1999)

PubMed=11005564; DOI=10.1038/sj.neo.7900094
Kohno T., Sato T., Takakura S., Takei K., Inoue K., Nishioka M., Yokota J.
Mutation and expression of the DCC gene in human lung cancer.
Neoplasia 2:300-305(2000)

PubMed=17332333; DOI=10.1158/0008-5472.CAN-06-3339
Okabe T., Okamoto I., Tamura K., Terashima M., Yoshida T., Satoh T., Takada M., Fukuoka M., Nakagawa K.
Differential constitutive activation of the epidermal growth factor receptor in non-small cell lung cancer cells bearing EGFR gene mutation and amplification.
Cancer Res. 67:2046-2053(2007)

PubMed=19472407; DOI=10.1002/humu.21028
Blanco R., Iwakawa R., Tang M.-Y., Kohno T., Angulo B., Pio R., Montuenga L.M., Minna J.D., Yokota J., Sanchez-Cespedes M.
A gene-alteration profile of human lung cancer cell lines.
Hum. Mutat. 30:1199-1206(2009)

PubMed=22313637; DOI=10.4161/cbt.19238
Takata M., Chikumi H., Miyake N., Adachi K., Kanamori Y., Yamasaki A., Igishi T., Burioka N., Nanba E., Shimizu E.
Lack of AKT activation in lung cancer cells with EGFR mutation is a novel marker of cetuximab sensitivity.
Cancer Biol. Ther. 13:369-378(2012)