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Cellosaurus Ma-1 (CVCL_7059)

[Text version]

Cell line name Ma-1
Synonyms Ma1
Accession CVCL_7059
Resource Identification Initiative To cite this cell line use: Ma-1 (RRID:CVCL_7059)
Comments Population: Japanese.
Doubling time: 25.9 hours (PubMed=1650680).
Sequence variations
  • Mutation; HGNC; 3236; EGFR; Simple; p.Glu746_Ala750del; Zygosity=Unspecified (PubMed=17332333).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Unspecified (PubMed=10536175).
Disease Lung adenocarcinoma (NCIt: C3512)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 64Y
Category Cancer cell line

PubMed=1650680; DOI=10.1378/chest.100.2.429
Masuda N., Fukuoka M., Takada M., Kudoh S., Kusunoki Y.
Establishment and characterization of 20 human non-small cell lung cancer cell lines in a serum-free defined medium (ACL-4).
Chest 100:429-438(1991)

PubMed=9393586; DOI=10.1007/s004320050101
Shimizu E., Zhao M., Shinohara A., Namikawa O., Ogura T., Masuda N., Takada M., Fukuoka M., Sone S.
Differential expressions of cyclin A and the retinoblastoma gene product in histological subtypes of lung cancer cell lines.
J. Cancer Res. Clin. Oncol. 123:533-538(1997)

PubMed=10536175; DOI=10.3892/ijo.15.5.927
Fujita T., Kiyama M., Tomizawa Y., Kohno T., Yokota J.
Comprehensive analysis of p53 gene mutation characteristics in lung carcinoma with special reference to histological subtypes.
Int. J. Oncol. 15:927-934(1999)

PubMed=11005564; DOI=10.1038/sj.neo.7900094
Kohno T., Sato T., Takakura S., Takei K., Inoue K., Nishioka M., Yokota J.
Mutation and expression of the DCC gene in human lung cancer.
Neoplasia 2:300-305(2000)

PubMed=17332333; DOI=10.1158/0008-5472.CAN-06-3339
Okabe T., Okamoto I., Tamura K., Terashima M., Yoshida T., Satoh T., Takada M., Fukuoka M., Nakagawa K.
Differential constitutive activation of the epidermal growth factor receptor in non-small cell lung cancer cells bearing EGFR gene mutation and amplification.
Cancer Res. 67:2046-2053(2007)

PubMed=19472407; DOI=10.1002/humu.21028
Blanco R., Iwakawa R., Tang M., Kohno T., Angulo B., Pio R., Montuenga L.M., Minna J.D., Yokota J., Sanchez-Cespedes M.
A gene-alteration profile of human lung cancer cell lines.
Hum. Mutat. 30:1199-1206(2009)

PubMed=22313637; DOI=10.4161/cbt.19238
Takata M., Chikumi H., Miyake N., Adachi K., Kanamori Y., Yamasaki A., Igishi T., Burioka N., Nanba E., Shimizu E.
Lack of AKT activation in lung cancer cells with EGFR mutation is a novel marker of cetuximab sensitivity.
Cancer Biol. Ther. 13:369-378(2012)

Anatomy/cell type resources BTO; BTO:0004160
Encyclopedic resources Wikidata; Q54903678
Polymorphism and mutation databases Cosmic; 801593
Cosmic; 844836
Cosmic; 876145
Cosmic; 917983
Cosmic; 1047095
Cosmic; 1128252
Cosmic; 1239874
Cosmic; 1656895
Cosmic; 2125271
Cosmic; 2668313
IARC_TP53; 11879
Entry history
Entry creation04-Apr-2012
Last entry update23-Sep-2021
Version number16