ID   Ma-1
AC   CVCL_7059
SY   Ma1
DR   BTO; BTO:0004160
DR   Cosmic; 801593
DR   Cosmic; 844836
DR   Cosmic; 876145
DR   Cosmic; 917983
DR   Cosmic; 1047095
DR   Cosmic; 1128252
DR   Cosmic; 1239874
DR   Cosmic; 1656895
DR   Cosmic; 2125271
DR   Cosmic; 2668313
DR   IARC_TP53; 11879
DR   Wikidata; Q54903678
RX   PubMed=1650680;
RX   PubMed=9393586;
RX   PubMed=10536175;
RX   PubMed=11005564;
RX   PubMed=17332333;
RX   PubMed=19472407;
RX   PubMed=22313637;
CC   Population: Japanese.
CC   Doubling time: 25.9 hours (PubMed=1650680).
CC   Sequence variation: Mutation; HGNC; 3236; EGFR; Simple; p.Glu746_Ala750del; Zygosity=Unspecified (PubMed=17332333).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Unspecified (PubMed=10536175).
CC   Derived from metastatic site: Pleural effusion.
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens
SX   Male
AG   64Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 23-09-21; Version: 16
//
RX   PubMed=1650680; DOI=10.1378/chest.100.2.429;
RA   Masuda N., Fukuoka M., Takada M., Kudoh S., Kusunoki Y.;
RT   "Establishment and characterization of 20 human non-small cell lung
RT   cancer cell lines in a serum-free defined medium (ACL-4).";
RL   Chest 100:429-438(1991).
//
RX   PubMed=9393586; DOI=10.1007/s004320050101;
RA   Shimizu E., Zhao M., Shinohara A., Namikawa O., Ogura T., Masuda N.,
RA   Takada M., Fukuoka M., Sone S.;
RT   "Differential expressions of cyclin A and the retinoblastoma gene
RT   product in histological subtypes of lung cancer cell lines.";
RL   J. Cancer Res. Clin. Oncol. 123:533-538(1997).
//
RX   PubMed=10536175; DOI=10.3892/ijo.15.5.927;
RA   Fujita T., Kiyama M., Tomizawa Y., Kohno T., Yokota J.;
RT   "Comprehensive analysis of p53 gene mutation characteristics in lung
RT   carcinoma with special reference to histological subtypes.";
RL   Int. J. Oncol. 15:927-934(1999).
//
RX   PubMed=11005564; DOI=10.1038/sj.neo.7900094;
RA   Kohno T., Sato T., Takakura S., Takei K., Inoue K., Nishioka M.,
RA   Yokota J.;
RT   "Mutation and expression of the DCC gene in human lung cancer.";
RL   Neoplasia 2:300-305(2000).
//
RX   PubMed=17332333; DOI=10.1158/0008-5472.CAN-06-3339;
RA   Okabe T., Okamoto I., Tamura K., Terashima M., Yoshida T., Satoh T.,
RA   Takada M., Fukuoka M., Nakagawa K.;
RT   "Differential constitutive activation of the epidermal growth factor
RT   receptor in non-small cell lung cancer cells bearing EGFR gene
RT   mutation and amplification.";
RL   Cancer Res. 67:2046-2053(2007).
//
RX   PubMed=19472407; DOI=10.1002/humu.21028;
RA   Blanco R., Iwakawa R., Tang M., Kohno T., Angulo B., Pio R.,
RA   Montuenga L.M., Minna J.D., Yokota J., Sanchez-Cespedes M.;
RT   "A gene-alteration profile of human lung cancer cell lines.";
RL   Hum. Mutat. 30:1199-1206(2009).
//
RX   PubMed=22313637; DOI=10.4161/cbt.19238;
RA   Takata M., Chikumi H., Miyake N., Adachi K., Kanamori Y., Yamasaki A.,
RA   Igishi T., Burioka N., Nanba E., Shimizu E.;
RT   "Lack of AKT activation in lung cancer cells with EGFR mutation is a
RT   novel marker of cetuximab sensitivity.";
RL   Cancer Biol. Ther. 13:369-378(2012).
//