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Cellosaurus SMS-KCN (CVCL_7133)

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Cell line name SMS-KCN
Synonyms KCN; SMS-KCNs; NB07C
Accession CVCL_7133
Resource Identification Initiative To cite this cell line use: SMS-KCN (RRID:CVCL_7133)
Comments Characteristics: Substrate-adherent type (S-type) (PubMed=15720811).
Doubling time: ~109 hours (PubMed=3456456).
Omics: CNV analysis.
Omics: Deep exome analysis.
Omics: Deep tyrosine phosphoproteome analysis.
Omics: Genome sequenced.
Omics: Transcriptome analysis.
Sequence variations ALK p.Arg1275Gln (c.3824G>A) (PubMed=18724359).
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_RK69 (SMS-KCN-69n)CVCL_WM95 (SMS-KCN-A)CVCL_WZ30 (SMS-KCN11s)
CVCL_WZ31 (SMS-KCN5n)
Originate from same individual CVCL_AQ28 ! SMS-KCL
CVCL_7134 ! SMS-KCNR
Sex of cell Male
Age at sampling 11M
Category Cancer cell line
STR profile Source(s): COG

Markers:
AmelogeninX,Y
CSF1PO10
D2S133817,22
D3S135814,15
D5S81811
D7S8209,11
D8S117913,14
D13S31712,13
D16S53910,11
D18S5115,19
D19S43314,15
D21S1130,31.2
FGA19,22
TH019.3
TPOX11
vWA17,18

Run an STR similarity search on this cell line
Web pages http://www.cogcell.org/dl/NB_Data_Sheets/SMS-KCN_Cell_Line_Data_Sheet_COGcell_org.pdf
Publications

PubMed=7037175
Reynolds C.P., Reynolds D.A., Frenkel E.P., Smith R.G.
Selective toxicity of 6-hydroxydopamine and ascorbate for human neuroblastoma in vitro: a model for clearing marrow prior to autologous transplant.
Cancer Res. 42:1331-1336(1982)

PubMed=3456456; DOI=10.1093/jnci/76.3.375
Reynolds C.P., Biedler J.L., Spengler B.A., Reynolds D.A., Ross R.A., Frenkel E.P., Smith R.G.
Characterization of human neuroblastoma cell lines established before and after therapy.
J. Natl. Cancer Inst. 76:375-387(1986)

PubMed=2535691
Ciccarone V., Spengler B.A., Meyers M.B., Biedler J.L., Ross R.A.
Phenotypic diversification in human neuroblastoma cells: expression of distinct neural crest lineages.
Cancer Res. 49:219-225(1989)

PubMed=2019470; DOI=10.1002/ijc.2910480221
Sugimoto T., Ueyama H., Hosoi H., Inazawa J., Kato T., Kemshead J.T., Reynolds C.P., Gown A.M., Mine H., Sawada T.
Alpha-smooth-muscle actin and desmin expressions in human neuroblastoma cell lines.
Int. J. Cancer 48:277-283(1991)

DOI=10.1016/B978-0-12-333530-2.50006-X
Israel M.A., Thiele C.J.
Tumor cell lines of the peripheral nervous system.
(In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.43-78; Academic Press; New York (1994)

DOI=10.1007/0-306-46872-7_2
Thiele C.J.
Neuroblastoma.
(In) Human cell culture. Vol. 1. Cancer Cell Lines part 1; Masters J.R.W., Palsson B.O. (eds.); pp.21-53; Kluwer Academic Publishers; New York (1999)

PubMed=12702577
Saito-Ohara F., Imoto I., Inoue J., Hosoi H., Nakagawara A., Sugimoto T., Inazawa J.
PPM1D is a potential target for 17q gain in neuroblastoma.
Cancer Res. 63:1876-1883(2003)

PubMed=15150091; DOI=10.1158/0008-5472.CAN-03-0809
Schaefer K.-L., Brachwitz K., Wai D.H., Braun Y., Diallo R., Korsching E., Eisenacher M., Voss R., van Valen F., Baer C., Selle B., Spahn L., Liao S.-K., Lee K.A.W., Hogendoorn P.C.W., Reifenberger G., Gabbert H.E., Poremba C.
Expression profiling of t(12;22) positive clear cell sarcoma of soft tissue cell lines reveals characteristic up-regulation of potential new marker genes including ERBB3.
Cancer Res. 64:3395-3405(2004)

PubMed=15720811; DOI=10.1593/neo.04310
Walton J.D., Kattan D.R., Thomas S.K., Spengler B.A., Guo H.-F., Biedler J.L., Cheung N.-K.V., Ross R.A.
Characteristics of stem cells from human neuroblastoma cell lines and in tumors.
Neoplasia 6:838-845(2004)

PubMed=16822308; DOI=10.1186/1471-2407-6-177
Dam V., Morgan B.T., Mazanek P., Hogarty M.D.
Mutations in PIK3CA are infrequent in neuroblastoma.
BMC Cancer 6:177-177(2006)

PubMed=18724359; DOI=10.1038/nature07261
Mosse Y.P., Laudenslager M., Longo L., Cole K.A., Wood A., Attiyeh E.F., Laquaglia M.J., Sennett R., Lynch J.E., Perri P., Laureys G., Speleman F., Kim C., Hou C., Hakonarson H., Torkamani A., Schork N.J., Brodeur G.M., Tonini G.P., Rappaport E., Devoto M., Maris J.M.
Identification of ALK as a major familial neuroblastoma predisposition gene.
Nature 455:930-935(2008)

PubMed=23202128; DOI=10.1038/ng.2493
Sausen M., Leary R.J., Jones S., Wu J., Reynolds C.P., Liu X., Blackford A.L., Parmigiani G., Diaz L.A. Jr., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E., Hogarty M.D.
Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma.
Nat. Genet. 45:12-17(2013)

PubMed=24792489; DOI=10.1007/s11060-014-1456-8
Farooqi A.S., Dagg R.A., Choi L.M.R., Shay J.W., Reynolds C.P., Lau L.M.S.
Alternative lengthening of telomeres in neuroblastoma cell lines is associated with a lack of MYCN genomic amplification and with p53 pathway aberrations.
J. Neurooncol. 119:17-26(2014)

PubMed=25884760; DOI=10.1371/journal.pcbi.1004130
Palacios-Moreno J., Foltz L., Guo A., Stokes M.P., Kuehn E.D., George L., Comb M., Grimes M.L.
Neuroblastoma tyrosine kinase signaling networks involve FYN and LYN in endosomes and lipid rafts.
PLoS Comput. Biol. 11:E1004130-E1004130(2015)

PubMed=26342562; DOI=10.1016/j.scr.2015.08.008
Ross R.A., Walton J.D., Han D., Guo H.-F., Cheung N.-K.V.
A distinct gene expression signature characterizes human neuroblastoma cancer stem cells.
Stem Cell Res. 15:419-426(2015)

Cross-references
Cell line databases/resources CGH-DB; 71-1
CGH-DB; 9091-4
Ontologies BTO; BTO:0003548
Other Wikidata; Q54954990
Polymorphism and mutation databases Cosmic; 717426
Cosmic; 848940
Cosmic; 923827
Cosmic; 1019932
Cosmic; 1162007
Cosmic; 1890077
Cosmic; 2393632
Entry history
Entry creation04-Apr-2012
Last entry updated12-Mar-2020
Version number18