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Cellosaurus MPanc-96 (CVCL_7165)

[Text version]

Cell line name MPanc-96
Synonyms Mpanc-96; MPanc96; mPanc96; MPANC96
Accession CVCL_7165
Resource Identification Initiative To cite this cell line use: MPanc-96 (RRID:CVCL_7165)
Comments Problematic cell line: Contaminated. Shown to be a AsPC-1 derivative (PubMed=20143388). Originally thought to originate from a 67 year old male patient with a poorly differentiated primary pancreatic adenocarcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00329.
Population: Caucasian.
Doubling time: 27 hours (PubMed=9185703).
Omics: Proteome analysis by 2D-DE/MS.
Misspelling: Mpan96; In Cosmic 1299303.
Sequence variations Gene deletion; HGNC; 6844; MAP2K4; Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; 1787; CDKN2A; Simple; p.Leu78Hisfs*41 (c.233_234delTC) (p.His93Profs*67, c.276_277delTC); ClinVar=VCV000977782; Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Homozygous (PubMed=15367885).
Mutation; HGNC; 6770; SMAD4; Simple; p.Arg100Thr (c.299G>C); Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Cys135Alafs*35 (c.403delT); Zygosity=Heterozygous (PubMed=15367885).
Disease Pancreatic ductal adenocarcinoma (NCIt: C9120)
Derived from metastatic site: Ascites.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0152 (AsPC-1)
Sex of cell Female
Age at sampling 62Y
Category Cancer cell line
STR profile Source(s): ATCC

Markers:
AmelogeninX
CSF1PO10,13
D5S81812
D7S82012,13
D13S3179,12
D16S53911
TH017,9.3
TPOX8,10
vWA17

Run an STR similarity search on this cell line
Web pages https://www.atcc.org/en/support/technical-support/faqs/mpanc-96-atcc-crl-2380
http://iclac.org/wp-content/uploads/Cross-Contaminations_v11_distribution.xlsx
Publications

PubMed=9185703; DOI=10.1002/(SICI)1097-0215(19970611)71:6<993::AID-IJC15>3.0.CO;2-7
Peiper M., Nagoshi M., Patel D., Fletcher J.A., Goegebuure P.S., Eberlein T.J.
Human pancreatic cancer cells (MPanc-96) recognized by autologous tumor-infiltrating lymphocytes after in vitro as well as in vivo tumor expansion.
Int. J. Cancer 71:993-999(1997)

PubMed=15367885; DOI=10.1097/00006676-200410000-00004
Loukopoulos P., Kanetaka K., Takamura M., Shibata T., Sakamoto M., Hirohashi S.
Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity.
Pancreas 29:193-203(2004)

DOI=10.4172/jpb.1000057
Masayo Y., Kiyonaga F., Koji K., Setsuo H., Tadashi K.
The proteomic profile of pancreatic cancer cell lines corresponding to carcinogenesis and metastasis.
J. Proteomics Bioinformatics 2:1-18(2009)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Cell line collections ATCC; CRL-2380 - Discontinued
Biological sample resources BioSample; SAMN03151612
Encyclopedic resources Wikidata; Q54906434
Gene expression databases GEO; GSM784704
Polymorphism and mutation databases Cosmic; 913309
Cosmic; 1299303
Cosmic; 1571780
IARC_TP53; 20487
Progenetix; CVCL_7165
Entry history
Entry creation04-Apr-2012
Last entry update23-Sep-2021
Version number26