ID   CHO-MG
AC   CVCL_7181
SY   CHOMG; CHO MG; Pro-3 MG(R) 2-2
DR   BTO; BTO:0004065
DR   ChEMBL-Cells; CHEMBL3307646
DR   ChEMBL-Targets; CHEMBL614558
DR   PubChem_Cell_line; CVCL_7181
DR   Wikidata; Q54813079
RX   PubMed=730773;
RX   PubMed=2766456;
RX   PubMed=2782395;
CC   Selected for resistance to: ChEBI; CHEBI:43996; Mitoguazone (Methylglyoxal bis-(guanylhydrazone); MGBG).
CC   Transformant: ChEBI; CHEBI:23994; Ethyl methanesulfonate (Methylsulfonic acid ethyl ester; MSEE).
CC   Caution: Four MGBG-resistant cell lines (Pro-3 MG(R) 1-23, Pro-3 MG(R) 2-2, Pro-3 MG(R) 3-1 and Pro-6 MG(R) 4-8) were created (PubMed=730773). As it is not clear which cell line has been distributed under the name CHO-MG, we have selected Pro-3 MG(R) 2-2 as it is used extensively in the original paper.
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
CC   Cell type: Epithelial cell of ovary; CL=CL_2000064.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_7182 ! CHO Pro-3
SX   Female
AG   Adult
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 13
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RX   PubMed=730773; DOI=10.1002/jcp.1040970308;
RA   Mandel J.-L., Flintoff W.F.;
RT   "Isolation of mutant mammalian cells altered in polyamine transport.";
RL   J. Cell. Physiol. 97:335-343(1978).
//
RX   PubMed=2766456; DOI=10.1093/carcin/10.9.1613;
RA   Dolan M.E., Norbeck L., Clyde C., Hora N.K., Erickson L.C., Pegg A.E.;
RT   "Expression of mammalian O6-alkylguanine-DNA alkyltransferase in a
RT   cell line sensitive to alkylating agents.";
RL   Carcinogenesis 10:1613-1619(1989).
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RX   PubMed=2782395; DOI=10.1152/ajpcell.1989.257.3.C545;
RA   Byers T.L., Pegg A.E.;
RT   "Properties and physiological function of the polyamine transport
RT   system.";
RL   Am. J. Physiol. 257:C545-C553(1989).
//