ID   INS-1 832/13
AC   CVCL_7226
SY   INS1 832/13; INS-1 (832/13); INS 832/13 ; 832/13; 832/13 INS-1
DR   BCGO; BCGO_0000115
DR   BTO; BTO:0003318
DR   AddexBio; C0018024/5026
DR   Lonza; 11
DR   MetaboLights; MTBLS951
DR   Millipore; SCC207
DR   TOKU-E; 4125
DR   Wikidata; Q54897743
RX   PubMed=10868964;
RX   PubMed=18755687;
RX   PubMed=23555872;
CC   Characteristics: Shows robust glucose-stimulated insulin secretion (GSIS) (Millipore).
CC   Transfected with: HGNC; 6081; INS.
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCIt; C17262; X-Ray.
CC   Misspelling: INS-1 823/13; Occasionally.
CC   Misspelling: 823/13; Occasionally.
CC   Derived from sampling site: Pancreas; islets of Langerhans.
CC   Breed/subspecies: NEDH.
DI   NCIt; C121566; Rat insulinoma
OX   NCBI_TaxID=10116; ! Rattus norvegicus
HI   CVCL_0352 ! INS-1
SX   Male
AG   666D
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 23-09-21; Version: 17
//
RX   PubMed=10868964; DOI=10.2337/diabetes.49.3.424;
RA   Hohmeier H.E., Mulder H., Chen G.-X., Henkel-Rieger R., Prentki M.,
RA   Newgard C.B.;
RT   "Isolation of INS-1-derived cell lines with robust ATP-sensitive K+
RT   channel-dependent and -independent glucose-stimulated insulin
RT   secretion.";
RL   Diabetes 49:424-430(2000).
//
RX   PubMed=18755687; DOI=10.1074/jbc.M804665200;
RA   Ronnebaum S.M., Jensen M.V., Hohmeier H.E., Burgess S.C., Zhou Y.-P.,
RA   Qian S., MacNeil D., Howard A., Thornberry N., Ilkayeva O., Lu D.-H.,
RA   Sherry A.D., Newgard C.B.;
RT   "Silencing of cytosolic or mitochondrial isoforms of malic enzyme has
RT   no effect on glucose-stimulated insulin secretion from rodent
RT   islets.";
RL   J. Biol. Chem. 283:28909-28917(2008).
//
RX   PubMed=23555872; DOI=10.1371/journal.pone.0060030;
RA   Hectors T.L.M., Vanparys C., Pereira-Fernandes A., Martens G.A.,
RA   Blust R.;
RT   "Evaluation of the INS-1 832/13 cell line as a beta-cell based
RT   screening system to assess pollutant effects on beta-cell function.";
RL   PLoS ONE 8:E60030-E60030(2013).
//