ID   GM00637
AC   CVCL_7297
SY   GM-637; GM 637; GM637; GM0637; GM637A; GM637-SV; GM00637B; GM00637F; GM00637H; GM00637I; HG2855
DR   BTO; BTO:0003591
DR   CLO; CLO_0003514
DR   CLO; CLO_0028881
DR   CLDB; cl1481
DR   Coriell; GM00637
DR   IPD-IMGT/HLA; 10615
DR   TOKU-E; 4106
DR   Wikidata; Q54836363
RX   CelloPub=CLPUB00447;
RX   CelloPub=CLPUB00712;
RX   DOI=10.2307/1308677;
RX   DOI=10.5962/bhl.title.4090;
RX   PubMed=198418;
RX   PubMed=2011574;
RX   PubMed=2762303;
RX   PubMed=2821020;
RX   PubMed=2903889;
RX   PubMed=3023120;
RX   PubMed=3180052;
RX   PubMed=6256643;
RX   PubMed=7273335;
RX   PubMed=8069455;
RX   PubMed=8464385;
RX   PubMed=8808599;
RX   PubMed=9650596;
RX   PubMed=10521302;
RX   PubMed=11172010;
RX   PubMed=12060391;
RX   PubMed=12361951;
RX   PubMed=14662655;
RX   PubMed=16081512;
RX   PubMed=16520097;
RX   PubMed=16714754;
RX   PubMed=18433479;
RX   PubMed=18470933;
RX   PubMed=18955168;
RX   PubMed=19935656;
CC   Population: Puerto Rican.
CC   Characteristics: Cell line positive for alternative lengthening of telomeres (ALT+) (CelloPub=CLPUB00712; PubMed=19935656).
CC   HLA typing: A*02:01:01:01,26:01:01; C*15:02:01,16:01:01 (IPD-IMGT/HLA=10615).
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Derived from site: In situ; Skin; UBERON=UBERON_0002097.
CC   Cell type: Fibroblast of skin; CL=CL_0002620.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_7270 ! GM00037
SX   Female
AG   18Y
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 30
//
RX   CelloPub=CLPUB00447;
RA   Mulivor R.A., Suchy S.F.;
RT   "1992/1993 catalog of cell lines. NIGMS human genetic mutant cell
RT   repository. 16th edition. October 1992.";
RL   (In) Institute for Medical Research (Camden, N.J.) NIH 92-2011; pp.1-918; National Institutes of Health; Bethesda (1992).
//
RX   CelloPub=CLPUB00712;
RA   Henson J.D.;
RT   "The role of alternative lengthening of telomeres in human cancer.";
RL   Thesis PhD (2006), University of Sydney, Australia.
//
RX   DOI=10.2307/1308677;
RA   Day R.S. III;
RT   "Adenovirus: a probe for human cells deficient in DNA repair.";
RL   BioScience 31:807-813(1981).
//
RX   DOI=10.5962/bhl.title.4090;
RA   Coriell L.L., Greene A.E.;
RT   "The human genetic mutant cell repository: list of genetic variants,
RT   chromosomal aberrations and normal cell cultures submitted to the
RT   repository. 4th edition. October 1977.";
RL   (In) Institute for Medical Research (Camden, N.J.); pp.1-171; National Institutes of Health; Bethesda (1977).
//
RX   PubMed=198418; DOI=10.1002/jcp.1040930116;
RA   Oshima R.G., Pellett O.L., Robb J.A., Schneider J.A.;
RT   "Transformation of human cystinotic fibroblasts by SV40:
RT   characteristics of transformed cells with limited and unlimited growth
RT   potential.";
RL   J. Cell. Physiol. 93:129-136(1977).
//
RX   PubMed=2011574; DOI=10.1073/pnas.88.7.2633;
RA   Reichardt J.K.V., Woo S.L.C.;
RT   "Molecular basis of galactosemia: mutations and polymorphisms in the
RT   gene encoding human galactose-1-phosphate uridylyltransferase.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:2633-2637(1991).
//
RX   PubMed=2762303; DOI=10.1073/pnas.86.15.5893;
RA   Fukuchi K.-i., Martin G.M., Monnat R.J. Jr.;
RT   "Mutator phenotype of Werner syndrome is characterized by extensive
RT   deletions.";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:5893-5897(1989).
//
RX   PubMed=2821020; DOI=10.1242/jcs.1984.Supplement_6.8;
RA   Green M.H.L., Lowe J.E., Arlett C.F., Harcourt S.A., Burke J.F.,
RA   James M.R., Lehmann A.R., Povey S.;
RT   "A gamma-ray-resistant derivative of an ataxia telangiectasia cell
RT   line obtained following DNA-mediated gene transfer.";
RL   J. Cell Sci. Suppl. 6:127-137(1987).
//
RX   PubMed=2903889; DOI=10.1080/09553008814552321;
RA   Arlett C.F., Green M.H.L., Priestley A., Harcourt S.A., Mayne L.V.;
RT   "Comparative human cellular radiosensitivity: I. The effect of SV40
RT   transformation and immortalisation on the gamma-irradiation survival
RT   of skin derived fibroblasts from normal individuals and from
RT   ataxia-telangiectasia patients and heterozygotes.";
RL   Int. J. Radiat. Biol. 54:911-928(1988).
//
RX   PubMed=3023120; DOI=10.1016/0014-4827(87)90418-6;
RA   Hahn P., Kapp L.N., Painter R.B.;
RT   "Establishment and characterization of two human cell lines with
RT   amplified dihydrofolate reductase genes.";
RL   Exp. Cell Res. 168:89-94(1987).
//
RX   PubMed=3180052;
RA   Lehmann A.R., Willis A.E., Broughton B.C., James M.R.,
RA   Steingrimsdottir H., Harcourt S.A., Arlett C.F., Lindahl T.R.;
RT   "Relation between the human fibroblast strain 46BR and cell lines
RT   representative of Bloom's syndrome.";
RL   Cancer Res. 48:6343-6347(1988).
//
RX   PubMed=6256643; DOI=10.1038/288724a0;
RA   Day R.S. III, Ziolkowski C.H.J., Scudiero D.A., Meyer S.A.,
RA   Lubiniecki A.S., Girardi A.J., Galloway S.M., Bynum G.D.;
RT   "Defective repair of alkylated DNA by human tumour and
RT   SV40-transformed human cell strains.";
RL   Nature 288:724-727(1980).
//
RX   PubMed=7273335; DOI=10.1093/carcin/2.6.567;
RA   Simon L., Hazard R.M., Maher V.M., McCormick J.J.;
RT   "Enhanced cell killing and mutagenesis by ethylnitrosourea in
RT   xeroderma pigmentosum cells.";
RL   Carcinogenesis 2:567-570(1981).
//
RX   PubMed=8069455; DOI=10.1007/BF02631450;
RA   Fukuchi K.-i., Hearn M.G., Deeb S.S., Smith A.C., Ngoc Thao D.,
RA   Miyazaki J.-i., Bothwell M., Martin G.M.;
RT   "Activity assays of nine heterogeneous promoters in neural and other
RT   cultured cells.";
RL   In Vitro Cell. Dev. Biol. Anim. 30:300-305(1994).
//
RX   PubMed=8464385; DOI=10.1093/mutage/8.2.155;
RA   McDowell M.L., Nguyen T., Cleaver J.E.;
RT   "A single-site mutation in the XPAC gene alters photoproduct
RT   recognition.";
RL   Mutagenesis 8:155-161(1993).
//
RX   PubMed=8808599;
RA   Wright J., Teraoka S., Onengut S., Tolun A., Gatti R.A., Ochs H.D.,
RA   Concannon P.;
RT   "A high frequency of distinct ATM gene mutations in
RT   ataxia-telangiectasia.";
RL   Am. J. Hum. Genet. 59:839-846(1996).
//
RX   PubMed=9650596; DOI=10.2307/3579639;
RA   Enns L., Barley R.D.C., Paterson M.C., Mirzayans R.;
RT   "Radiosensitivity in ataxia telangiectasia fibroblasts is not
RT   associated with deregulated apoptosis.";
RL   Radiat. Res. 150:11-16(1998).
//
RX   PubMed=10521302; DOI=10.1086/302616;
RA   Ellis N.A., Proytcheva M., Sanz M.M., Ye T.-Z., German J.L. III;
RT   "Transfection of BLM into cultured Bloom syndrome cells reduces the
RT   sister-chromatid exchange rate toward normal.";
RL   Am. J. Hum. Genet. 65:1368-1374(1999).
//
RX   PubMed=11172010; DOI=10.1073/pnas.041416598;
RA   Peretz S., Jensen R., Baserga R., Glazer P.M.;
RT   "ATM-dependent expression of the insulin-like growth factor-I receptor
RT   in a pathway regulating radiation response.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:1676-1681(2001).
//
RX   PubMed=12060391; DOI=10.1046/j.1523-1747.2002.01782.x;
RA   Emmert S., Slor H., Busch D.B., Batko S., Albert R.B., Coleman D.M.,
RA   Khan S.G., Abu-Libdeh B., DiGiovanna J.J., Cunningham B.B., Lee M.-M.,
RA   Crollick J., Inui H., Ueda T., Hedayati M., Grossman L., Shahlavi T.,
RA   Cleaver J.E., Kraemer K.H.;
RT   "Relationship of neurologic degeneration to genotype in three
RT   xeroderma pigmentosum group G patients.";
RL   J. Invest. Dermatol. 118:972-982(2002).
//
RX   PubMed=12361951; DOI=10.1074/jbc.M207937200;
RA   Donahue S.L., Campbell C.;
RT   "A DNA double strand break repair defect in Fanconi anemia
RT   fibroblasts.";
RL   J. Biol. Chem. 277:46243-46247(2002).
//
RX   PubMed=14662655; DOI=10.1093/hmg/ddh026;
RA   Khan S.G., Metin A., Gozukara E.M., Inui H., Shahlavi T.,
RA   Muniz-Medina V., Baker C.C., Ueda T., Aiken J.R., Schneider T.D.,
RA   Kraemer K.H.;
RT   "Two essential splice lariat branchpoint sequences in one intron in a
RT   xeroderma pigmentosum DNA repair gene: mutations result in reduced XPC
RT   mRNA levels that correlate with cancer risk.";
RL   Hum. Mol. Genet. 13:343-352(2004).
//
RX   PubMed=16081512; DOI=10.1093/carcin/bgi204;
RA   Khan S.G., Oh K.-S., Shahlavi T., Ueda T., Busch D.B., Inui H.,
RA   Emmert S., Imoto K., Muniz-Medina V., Baker C.C., DiGiovanna J.J.,
RA   Schmidt D., Khadavi A., Metin A., Gozukara E.M., Slor H., Sarasin A.,
RA   Kraemer K.H.;
RT   "Reduced XPC DNA repair gene mRNA levels in clinically normal parents
RT   of xeroderma pigmentosum patients.";
RL   Carcinogenesis 27:84-94(2006).
//
RX   PubMed=16520097; DOI=10.1016/j.dnarep.2006.01.008;
RA   Cruet-Hennequart S., Coyne S., Glynn M.T., Oakley G.G., Carty M.P.;
RT   "UV-induced RPA phosphorylation is increased in the absence of DNA
RT   polymerase eta and requires DNA-PK.";
RL   DNA Repair 5:491-504(2006).
//
RX   PubMed=16714754; DOI=10.1259/bjr/83726649;
RA   Arlett C.F., Plowman P.N., Rogers P.B., Parris C.N., Abbaszadeh F.,
RA   Green M.H.L., McMillan T.J., Bush C., Foray N., Lehmann A.R.;
RT   "Clinical and cellular ionizing radiation sensitivity in a patient
RT   with xeroderma pigmentosum.";
RL   Br. J. Radiol. 79:510-517(2006).
//
RX   PubMed=18433479; DOI=10.1186/1748-717X-3-12;
RA   Schwarz S.B., Schaffer P.M., Kulka U., Ertl-Wagner B., Hell R.,
RA   Schaffer M.;
RT   "The effect of radio-adaptive doses on HT29 and GM637 cells.";
RL   Radiat. Oncol. 3:12.1-12.6(2008).
//
RX   PubMed=18470933; DOI=10.1002/humu.20768;
RA   Boyle J., Ueda T., Oh K.-S., Imoto K., Tamura D., Jagdeo J., Khan S.G.,
RA   Nadem C., DiGiovanna J.J., Kraemer K.H.;
RT   "Persistence of repair proteins at unrepaired DNA damage distinguishes
RT   diseases with ERCC2 (XPD) mutations: cancer-prone xeroderma
RT   pigmentosum vs. non-cancer-prone trichothiodystrophy.";
RL   Hum. Mutat. 29:1194-1208(2008).
//
RX   PubMed=18955168; DOI=10.1016/j.dnarep.2008.09.007;
RA   Khan S.G., Oh K.-S., Emmert S., Imoto K., Tamura D., DiGiovanna J.J.,
RA   Shahlavi T., Armstrong N., Baker C.C., Neuburg M., Zalewski C.,
RA   Brewer C.C., Wiggs E., Schiffmann R., Kraemer K.H.;
RT   "XPC initiation codon mutation in xeroderma pigmentosum patients with
RT   and without neurological symptoms.";
RL   DNA Repair 8:114-125(2009).
//
RX   PubMed=19935656; DOI=10.1038/nbt.1587;
RA   Henson J.D., Cao Y., Huschtscha L.I., Chang A.C.-M., Au A.Y.M.,
RA   Pickett H.A., Reddel R.R.;
RT   "DNA C-circles are specific and quantifiable markers of
RT   alternative-lengthening-of-telomeres activity.";
RL   Nat. Biotechnol. 27:1181-1185(2009).
//