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Cellosaurus AT5BIVA (CVCL_7442)

[Text version]

Cell line name AT5BIVA
Synonyms AT5BiSv40; AT5BISV40; ATSV1; GM05849; GM5849; GM5849C; GM05849A; GM05849B
Accession CVCL_7442
Resource Identification Initiative To cite this cell line use: AT5BIVA (RRID:CVCL_7442)
Comments Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Misspelling: GM5489; In PubMed=2987007.
Derived from sampling site: Skin. Cell type=Fibroblast.
Sequence variations
  • Mutation; HGNC; 795; ATM; Simple; p.Leu2427_Arg2428del (c.7278_7283delCCTTAG); ClinVar=VCV000003020; Zygosity=Heterozygous (from parent cell line).
Disease Ataxia telangiectasia syndrome (NCIt: C2887)
Ataxia telangiectasia (ORDO: Orphanet_100)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_7441 (AT5BI)
Sex of cell Male
Age at sampling 18Y
Category Transformed cell line

PubMed=2987007; DOI=10.1016/0014-4827(85)90437-9
Murnane J.P., Fuller L.F., Painter R.B.
Establishment and characterization of a permanent pSV ori-transformed ataxia-telangiectasia cell line.
Exp. Cell Res. 158:119-126(1985)

PubMed=2821020; DOI=10.1242/jcs.1984.Supplement_6.8
Green M.H.L., Lowe J.E., Arlett C.F., Harcourt S.A., Burke J.F., James M.R., Lehmann A.R., Povey S.M.
A gamma-ray-resistant derivative of an ataxia telangiectasia cell line obtained following DNA-mediated gene transfer.
J. Cell Sci. Suppl. 6:127-137(1987)

PubMed=3023120; DOI=10.1016/0014-4827(87)90418-6
Hahn P., Kapp L.N., Painter R.B.
Establishment and characterization of two human cell lines with amplified dihydrofolate reductase genes.
Exp. Cell Res. 168:89-94(1987)

PubMed=2903889; DOI=10.1080/09553008814552321
Arlett C.F., Green M.H.L., Priestley A., Harcourt S.A., Mayne L.V.
Comparative human cellular radiosensitivity: I. The effect of SV40 transformation and immortalisation on the gamma-irradiation survival of skin derived fibroblasts from normal individuals and from ataxia-telangiectasia patients and heterozygotes.
Int. J. Radiat. Biol. 54:911-928(1988)

Mulivor R.A., Suchy S.F.
1992/1993 catalog of cell lines. NIGMS human genetic mutant cell repository. 16th edition. October 1992.
(In) Institute for Medical Research (Camden, N.J.) NIH 92-2011; pp.1-918; National Institutes of Health; Bethesda (1992)

PubMed=9650596; DOI=10.2307/3579639
Enns L., Barley R.D.C., Paterson M.C., Mirzayans R.
Radiosensitivity in ataxia telangiectasia fibroblasts is not associated with deregulated apoptosis.
Radiat. Res. 150:11-16(1998)

PubMed=11172010; DOI=10.1073/pnas.041416598
Peretz S., Jensen R., Baserga R., Glazer P.M.
ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response.
Proc. Natl. Acad. Sci. U.S.A. 98:1676-1681(2001)

PubMed=12419185; DOI=10.1016/s0960-9822(02)01259-9
Kobayashi J., Tauchi H., Sakamoto S., Nakamura A., Morishima K., Matsuura S., Kobayashi T., Tamai K., Tanimoto K., Komatsu K.
NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain.
Curr. Biol. 12:1846-1851(2002)

Shammas M.A., Shmookler Reis R.J., Akiyama M., Koley H., Chauhan D., Hideshima T., Goyal R.K., Hurley L.H., Anderson K.C., Munshi N.C.
Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma.
Mol. Cancer Ther. 2:825-833(2003)

PubMed=18757420; DOI=10.1158/0008-5472.CAN-08-0545
Burdak-Rothkamm S., Rothkamm K., Prise K.M.
ATM acts downstream of ATR in the DNA damage response signaling of bystander cells.
Cancer Res. 68:7059-7065(2008)

Cell line collections Coriell; GM05849
Cell line databases/resources CLO; CLO_0024705
Lonza; 258
TOKU-E; 4105
Encyclopedic resources Wikidata; Q54750948
Entry history
Entry creation04-Apr-2012
Last entry update16-Dec-2021
Version number22