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Cellosaurus GTL-16 (CVCL_7668)

[Text version]

Cell line name GTL-16
Synonyms GTL 16; GTL16
Accession CVCL_7668
Resource Identification Initiative To cite this cell line use: GTL-16 (RRID:CVCL_7668)
Comments Population: Japanese.
Characteristics: MET is amplified and overexpressed in this cell line.
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Mutation; HGNC; 11998; TP53; Simple; p.Arg110Cys (c.328C>T); ClinVar=VCV000142206; Zygosity=Heterozygous (from parent cell line).
Disease Gastric adenocarcinoma (NCIt: C4004)
Derived from metastatic site: Liver.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0434 (MKN45)
CVCL_7696 (PR-GTL-16)
Sex of cell Female
Age at sampling 62Y
Category Cancer cell line

PubMed=2541345; DOI=10.1038/339155a0
Giordano S., Ponzetto C., Di Renzo M.F., Cooper C.S., Comoglio P.M.
Tyrosine kinase receptor indistinguishable from the c-met protein.
Nature 339:155-156(1989)

Ponzetto C., Giordano S., Peverali F., Della Valle G., Abate M.L., Vaula G., Comoglio P.M.
c-met is amplified but not mutated in a cell line with an activated met tyrosine kinase.
Oncogene 6:553-559(1991)

PubMed=1486568; DOI=10.1016/0165-4608(92)90350-H
Rege-Cambrin G., Scaravaglio P., Carozzi F., Giordano S., Ponzetto C., Comoglio P.M., Saglio G.
Karyotypic analysis of gastric carcinoma cell lines carrying an amplified c-met oncogene.
Cancer Genet. Cytogenet. 64:170-173(1992)

PubMed=22745804; DOI=10.1371/journal.pone.0039653
Lee N.V., Lira M.E., Pavlicek A., Ye J., Buckman D., Bagrodia S., Srinivasa S.P., Zhao Y., Aparicio S., Rejto P.A., Christensen J.G., Ching K.A.
A novel SND1-BRAF fusion confers resistance to c-Met inhibitor PF-04217903 in GTL16 cells through MAPK activation.
PLoS ONE 7:E39653-E39653(2012)

PubMed=24807215; DOI=10.1038/ncomms4830
Liu J., McCleland M., Stawiski E.W., Gnad F., Mayba O., Haverty P.M., Durinck S., Chen Y.-J., Klijn C., Jhunjhunwala S., Lawrence M., Liu H., Wan Y., Chopra V., Yaylaoglu M.B., Yuan W., Ha C., Gilbert H.N., Reeder J., Pau G., Stinson J., Stern H.M., Manning G., Wu T.D., Neve R.M., de Sauvage F.J., Modrusan Z., Seshagiri S., Firestein R., Zhang Z.
Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.
Nat. Commun. 5:3830-3830(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

Ontologies EFO; EFO_0006578
Chemistry resources ChEMBL-Cells; CHEMBL3308698
ChEMBL-Targets; CHEMBL612708
PharmacoDB; GTL16_418_2019
Gene expression databases ArrayExpress; E-MTAB-2706
GEO; GSM685812
GEO; GSM686033
GEO; GSM686034
GEO; GSM843505
GEO; GSM1178098
GEO; GSM1178099
GEO; GSM1374485
GEO; GSM1374486
Other Wikidata; Q54871835
Polymorphism and mutation databases Cosmic; 755306
Cosmic; 755613
Cosmic; 887246
Cosmic; 1945868
Cosmic; 2069777
Cosmic; 2484973
Cosmic; 2807624
Progenetix; CVCL_7668
Entry history
Entry creation04-Apr-2012
Last entry update20-May-2021
Version number24