ID   HEI193
AC   CVCL_7670
SY   HEI-193; HEI 193; House Ear Institute 193
DR   BTO; BTO:0005037
DR   Wikidata; Q54882275
RX   PubMed=11836557;
RX   PubMed=17304235;
RX   PubMed=17868749;
RX   PubMed=28469964;
CC   Group: Patented cell line.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); PTA-4544.
CC   Doubling time: 12 hours (PubMed=17304235).
CC   Sequence variation: Mutation; HGNC; 7773; NF2; Simple; c.1575-1G>A; ClinVar=VCV001285395; Zygosity=Unspecified; Note=Splice acceptor mutation (PubMed=11836557).
CC   Transfected with: UniProtKB; P03126; Human papillomavirus type 16 protein E6.
CC   Transfected with: UniProtKB; P03129; Human papillomavirus type 16 protein E7.
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Derived from site: In situ; Peripheral nervous system, vestibular nerve; UBERON=UBERON_0003723.
CC   Cell type: Schwann cell; CL=CL_0002573.
DI   NCIt; C3274; Neurofibromatosis type 2
DI   NCIt; C3276; Vestibular schwannoma
DI   ORDO; Orphanet_637; Neurofibromatosis type 2
DI   ORDO; Orphanet_252175; Vestibular schwannoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   56Y
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 15
//
RX   PubMed=11836557; DOI=10.3892/ijo.20.3.475;
RA   Hung G., Li X.-K., Faudoa R., Xeu Z., Kluwe L., Rhim J.S., Slattery W.,
RA   Lim D.J.;
RT   "Establishment and characterization of a schwannoma cell line from a
RT   patient with neurofibromatosis 2.";
RL   Int. J. Oncol. 20:475-482(2002).
//
RX   PubMed=17304235; DOI=10.1038/sj.cgt.7701037;
RA   Prabhakar S., Messerli S.M., Stemmer-Rachamimov A.O., Liu T.-C.,
RA   Rabkin S.D., Martuza R.L., Breakefield X.O.;
RT   "Treatment of implantable NF2 schwannoma tumor models with oncolytic
RT   herpes simplex virus G47Delta.";
RL   Cancer Gene Ther. 14:460-467(2007).
//
RX   PubMed=17868749; DOI=10.1016/j.mrfmmm.2007.07.015;
RA   Lepont P., Stickney J.T., Foster L.A., Meng J.-J., Hennigan R.F.,
RA   Ip W.;
RT   "Point mutation in the NF2 gene of HEI-193 human schwannoma cells
RT   results in the expression of a merlin isoform with attenuated growth
RT   suppressive activity.";
RL   Mutat. Res. 637:142-151(2008).
//
RX   PubMed=28469964;
RA   Guo J.-M., Grovola M.R., Xie H., Coggins G.E., Duggan P., Hasan R.,
RA   Huang J.-L., Lin D.W., Song C., Witek G.M., Berritt S., Schultz D.C.,
RA   Field J.;
RT   "Comprehensive pharmacological profiling of neurofibromatosis cell
RT   lines.";
RL   Am. J. Cancer Res. 7:923-934(2017).
//