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Cellosaurus HCCLM6 (CVCL_7680)

[Text version]
Cell line name HCCLM6
Synonyms HCCLM-6; LM6
Accession CVCL_7680
Resource Identification Initiative To cite this cell line use: HCCLM6 (RRID:CVCL_7680)
Comments Population: Chinese.
Characteristics: Established from pulmonary metastatic lesions produced in nude mice by 6 rounds of subcutaneous inoculation of parent cell line.
Doubling time: 32 hours (PubMed=15146329).
Karyotypic information: Has lost chromosome Y.
Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV).
Sequence variations
  • Mutation; HGNC; 14310; BRD7; Simple; p.Glu277Glyfs*18 (c.830_831delAG); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 23177; KEAP1; Simple; p.Pro445Glnfs*13 (c.1334delC); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Glu51Ter (c.151G>T); ClinVar=VCV000568781; Zygosity=Unspecified (from parent cell line).
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6832 (HCCLM3)
Children:
CVCL_A5CU (HCCLM9)
Sex of cell Male
Age at sampling 39Y
Category Cancer cell line
Publications

PubMed=15146329; DOI=10.1007/s00432-004-0564-9
Li Y., Tian B., Yang J., Zhao L., Wu X., Ye S.-L., Liu Y.-K., Tang Z.-Y.
Stepwise metastatic human hepatocellular carcinoma cell model system with multiple metastatic potentials established through consecutive in vivo selection and studies on metastatic characteristics.
J. Cancer Res. Clin. Oncol. 130:460-468(2004)

PubMed=19335983; DOI=10.3760/cma.j.issn.1007-3418.2009.03.010
Zheng D., Liu B.-B., Liu Y.-K., Kang X.-N., Sun L., Guo K., Sun R.-X., Chen J., Zhao Y.
Analysis of the expression of Slit/Robo genes and the methylation status of their promoters in the hepatocellular carcinoma cell lines.
Zhonghua Gan Zang Bing Za Zhi 17:198-202(2009)

PubMed=32884988; DOI=10.1016/j.gendis.2019.12.008
Lin Y.-L., Li Y.
Study on the hepatocellular carcinoma model with metastasis.
Genes Dis. 7:336-350(2020)

Cross-references
Cell line databases/resources cancercelllines; CVCL_7680
Anatomy/cell type resources BTO; BTO:0004470
Encyclopedic resources Wikidata; Q54881838
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number15