ID   HCCLM6
AC   CVCL_7680
SY   HCCLM-6; LM6
DR   BTO; BTO:0004470
DR   cancercelllines; CVCL_7680
DR   Wikidata; Q54881838
RX   PubMed=15146329;
RX   PubMed=19335983;
RX   PubMed=32884988;
CC   Population: Chinese.
CC   Characteristics: Established from pulmonary metastatic lesions produced in nude mice by 6 rounds of subcutaneous inoculation of parent cell line.
CC   Doubling time: 32 hours (PubMed=15146329).
CC   Karyotypic information: Has lost chromosome Y.
CC   Sequence variation: Mutation; HGNC; 14310; BRD7; Simple; p.Glu277Glyfs*18 (c.830_831delAG); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 23177; KEAP1; Simple; p.Pro445Glnfs*13 (c.1334delC); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Glu51Ter (c.151G>T); ClinVar=VCV000568781; Zygosity=Unspecified (from parent cell line).
CC   Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV).
DI   NCIt; C7956; Adult hepatocellular carcinoma
DI   ORDO; Orphanet_210159; Adult hepatocellular carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_6832 ! HCCLM3
SX   Male
AG   39Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 15
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RX   PubMed=15146329; DOI=10.1007/s00432-004-0564-9;
RA   Li Y., Tian B., Yang J., Zhao L., Wu X., Ye S.-L., Liu Y.-K.,
RA   Tang Z.-Y.;
RT   "Stepwise metastatic human hepatocellular carcinoma cell model system
RT   with multiple metastatic potentials established through consecutive in
RT   vivo selection and studies on metastatic characteristics.";
RL   J. Cancer Res. Clin. Oncol. 130:460-468(2004).
//
RX   PubMed=19335983; DOI=10.3760/cma.j.issn.1007-3418.2009.03.010;
RA   Zheng D., Liu B.-B., Liu Y.-K., Kang X.-N., Sun L., Guo K., Sun R.-X.,
RA   Chen J., Zhao Y.;
RT   "Analysis of the expression of Slit/Robo genes and the methylation
RT   status of their promoters in the hepatocellular carcinoma cell
RT   lines.";
RL   Zhonghua Gan Zang Bing Za Zhi 17:198-202(2009).
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RX   PubMed=32884988; DOI=10.1016/j.gendis.2019.12.008;
RA   Lin Y.-L., Li Y.;
RT   "Study on the hepatocellular carcinoma model with metastasis.";
RL   Genes Dis. 7:336-350(2020).
//