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Cellosaurus UM-SCC-22A (CVCL_7731)

[Text version]

Cell line name UM-SCC-22A
Synonyms UMSCC-22A; UMSCC22A; SCC22A; UMC-22a; UMC22a; UM-22A; University of Michigan-Squamous Cell Carcinoma-22A
Accession CVCL_7731
Resource Identification Initiative To cite this cell line use: UM-SCC-22A (RRID:CVCL_7731)
Comments Part of: MD Anderson Cell Lines Project.
Doubling time: 31 +- 4 hours (PubMed=9139877).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: Genome sequenced (low read coverage).
Omics: Protein expression by reverse-phase protein arrays.
Derived from sampling site: Hypopharynx.
Sequence variations Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (PubMed=31541927).
Mutation; HGNC; 7133; KMT2D; Simple; p.Glu341Gln (c.1021G>C); Zygosity=Heterozygous (PubMed=31541927).
Mutation; HGNC; 7133; KMT2D; Simple; p.Leu1935Val (c.5803C>G); Zygosity=Heterozygous (PubMed=31541927).
Mutation; HGNC; 7881; NOTCH1; Simple; p.Glu1679Ter (c.5035G>T); Zygosity=Homozygous (PubMed=31541927).
Mutation; HGNC; 11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Heterozygous (PubMed=18006756; PubMed=23613873; PubMed=31541927).
Mutation; HGNC; 11998; TP53; Simple; c.993+1G>T; ClinVar=VCV000634766; Zygosity=Heterozygous; Note=Splice donor mutation (PubMed=18006756; PubMed=23613873; PubMed=31541927).
Disease Hypopharyngeal squamous cell carcinoma (NCIt: C4043)
Squamous cell carcinoma of the hypopharynx (ORDO: Orphanet_494547)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_7732 ! UM-SCC-22B
Sex of cell Female
Age at sampling 59Y
Category Cancer cell line
STR profile Source(s): Millipore; PubMed=19760794; PubMed=21868764

Markers:
AmelogeninX
CSF1PO10
D3S135816
D5S81812
D7S8208,9
D8S117911,13
D13S3178,12
D16S5399,11
D18S5118
D21S1128
FGA22,24
Penta D13
Penta E12,18
TH016
TPOX8,11
vWA15,18 (Millipore; PubMed=19760794_passage_16)
18 (PubMed=19760794_passage_138; PubMed=21868764)

Run an STR similarity search on this cell line
Web pages https://tcpaportal.org/mclp/
Publications

PubMed=1958593; DOI=10.1002/gcc.2870030406
Bradford C.R., Kimmel K.A., Van Dyke D.L., Worsham M.J., Tilley B.J., Burk D., del Rosario F., Lutz S., Tooley R., Hayashida D.J., Carey T.E.
11p deletions and breakpoints in squamous cell carcinoma: association with altered reactivity with the UM-E7 antibody.
Genes Chromosomes Cancer 3:272-282(1991)

DOI=10.1016/B978-0-12-333530-2.50007-1
Carey T.E.
Head and neck tumor cell lines.
(In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.79-120; Academic Press; New York (1994)

PubMed=9139877; DOI=10.1002/(SICI)1097-0215(19970502)71:3<410::AID-IJC18>3.0.CO;2-J
Welters M.J.P., Fichtinger-Schepman A.M.J., Baan R.A., Hermsen M.A.J.A., van der Vijgh W.J.F., Cloos J., Braakhuis B.J.M.
Relationship between the parameters cellular differentiation, doubling time and platinum accumulation and cisplatin sensitivity in a panel of head and neck cancer cell lines.
Int. J. Cancer 71:410-415(1997)

PubMed=15287027; DOI=10.1002/gcc.20066
Takebayashi S., Hickson A., Ogawa T., Jung K.-Y., Mineta H., Ueda Y., Grenman R., Fisher S.G., Carey T.E.
Loss of chromosome arm 18q with tumor progression in head and neck squamous cancer.
Genes Chromosomes Cancer 41:145-154(2004)

PubMed=17312569; DOI=10.1002/hed.20478
Lin C.J., Grandis J.R., Carey T.E., Gollin S.M., Whiteside T.L., Koch W.M., Ferris R.L., Lai S.Y.
Head and neck squamous cell carcinoma cell lines: established models and rationale for selection.
Head Neck 29:163-188(2007)

PubMed=18006756; DOI=10.1158/1078-0432.CCR-07-1591
Friedman J., Nottingham L., Duggal P., Pernas F.G., Yan B., Yang X.P., Chen Z., Van Waes C.
Deficient TP53 expression, function, and cisplatin sensitivity are restored by quinacrine in head and neck cancer.
Clin. Cancer Res. 13:6568-6578(2007)

PubMed=19760794; DOI=10.1002/hed.21198
Brenner J.C., Graham M.P., Kumar B., Saunders L.M., Kupfer R., Lyons R.H., Bradford C.R., Carey T.E.
Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell lines.
Head Neck 32:417-426(2010)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690
Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C., Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G., Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=23613873; DOI=10.1371/journal.pone.0061555
Martens-de Kemp S.R., Dalm S.U., Wijnolts F.M.J., Brink A., Honeywell R.J., Peters G.J., Braakhuis B.J.M., Brakenhoff R.H.
DNA-bound platinum is the major determinant of cisplatin sensitivity in head and neck squamous carcinoma cells.
PLoS ONE 8:E61555-E61555(2013)

PubMed=26122845; DOI=10.1158/0008-5472.CAN-15-0528
Stoepker C., Ameziane N., van der Lelij P., Kooi I.E., Oostra A.B., Rooimans M.A., van Mil S.E., Brink A., Dietrich R., Balk J.A., Ylstra B., Joenje H., Feller S.M., Brakenhoff R.H.
Defects in the Fanconi anemia pathway and chromatid cohesion in head and neck cancer.
Cancer Res. 75:3543-3553(2015)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=29156801; DOI=10.18632/oncotarget.21174
Kalu N.N., Mazumdar T., Peng S., Shen L., Sambandam V., Rao X., Xi Y., Li L., Qi Y., Gleber-Netto F.O., Patel A., Wang J., Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

PubMed=31541927; DOI=10.1016/j.oraloncology.2019.09.004
van Harten A.M., Poell J.B., Buijze M., Brink A., Wells S.I., Rene Leemans C., Wolthuis R.M.F., Brakenhoff R.H.
Characterization of a head and neck cancer-derived cell line panel confirms the distinct TP53-proficient copy number-silent subclass.
Oral Oncol. 98:53-61(2019)

Cross-references
Cell line collections Millipore; SCC076
Ontologies BTO; BTO:0002714
Other Wikidata; Q54990837
Polymorphism and mutation databases Cosmic; 948033
Cosmic; 1130357
Cosmic; 2439752
Cosmic; 2513913
IARC_TP53; 25908
Entry history
Entry creation04-Apr-2012
Last entry update20-May-2021
Version number22