Cellosaurus logo
expasy logo

Cellosaurus UM-SCC-46 (CVCL_7758)

[Text version]
Cell line name UM-SCC-46
Synonyms UMSCC-46; UMSCC46; University of Michigan-Squamous Cell Carcinoma-46
Accession CVCL_7758
Resource Identification Initiative To cite this cell line use: UM-SCC-46 (RRID:CVCL_7758)
Comments Omics: CNV analysis.
Omics: Deep exome analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Larynx; UBERON=UBERON_0001737.
Sequence variations
Disease Laryngeal squamous cell carcinoma (NCIt: C4044)
Squamous cell carcinoma of the larynx (ORDO: Orphanet_494550)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 57Y
Category Cancer cell line
STR profile Source(s): PubMed=19760794

Markers:
AmelogeninX
D3S135815
D5S81810,11
D7S82012,14
D8S117913,15
D13S31710
D18S5119
D21S1130,31.2
FGA21
vWA14,18

Run an STR similarity search on this cell line
Publications

PubMed=12884349; DOI=10.1002/hed.10274
Bradford C.R., Zhu S.-B., Ogawa H., Ogawa T., Ubell M., Narayan A., Johnson G., Wolf G.T., Fisher S.G., Carey T.E.
P53 mutation correlates with cisplatin sensitivity in head and neck squamous cell carcinoma lines.
Head Neck 25:654-661(2003)

PubMed=17312569; DOI=10.1002/hed.20478
Lin C.J., Grandis J.R., Carey T.E., Gollin S.M., Whiteside T.L., Koch W.M., Ferris R.L., Lai S.Y.
Head and neck squamous cell carcinoma cell lines: established models and rationale for selection.
Head Neck 29:163-188(2007)

PubMed=18006756; DOI=10.1158/1078-0432.CCR-07-1591
Friedman J., Nottingham L., Duggal P., Pernas F.G., Yan B., Yang X.-P., Chen Z., Van Waes C.
Deficient TP53 expression, function, and cisplatin sensitivity are restored by quinacrine in head and neck cancer.
Clin. Cancer Res. 13:6568-6578(2007)

PubMed=19760794; DOI=10.1002/hed.21198
Brenner J.C., Graham M.P., Kumar B., Saunders L.M., Kupfer R., Lyons R.H., Bradford C.R., Carey T.E.
Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell lines.
Head Neck 32:417-426(2010)

PubMed=31090975; DOI=10.1002/hed.25803
Mann J.E., Kulkarni A., Birkeland A.C., Kafelghazal J., Eisenberg J., Jewell B.M., Ludwig M.L., Spector M.E., Jiang H., Carey T.E., Brenner J.C.
The molecular landscape of the University of Michigan laryngeal squamous cell carcinoma cell line panel.
Head Neck 41:3114-3124(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_7758
Encyclopedic resources Wikidata; Q54990869
Gene expression databases GEO; GSM3631277
Polymorphism and mutation databases IARC_TP53; 18883
Progenetix; CVCL_7758
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number19