ID   GM00847
AC   CVCL_7908
SY   LN-SV; LNSV; GM-847; GM 847; GM847
DR   CLO; CLO_0029655
DR   Coriell; GM00847
DR   Wikidata; Q54836472
RX   CelloPub=CLPUB00447;
RX   CelloPub=CLPUB00712;
RX   DOI=10.5962/bhl.title.4090;
RX   PubMed=174085;
RX   PubMed=191830;
RX   PubMed=1260760;
RX   PubMed=3413074;
RX   PubMed=9175740;
RX   PubMed=11359895;
RX   PubMed=12361951;
RX   PubMed=19935656;
RX   PubMed=26001292;
CC   Population: African American.
CC   Characteristics: Cell line positive for alternative lengthening of telomeres (ALT+) (CelloPub=CLPUB00712; PubMed=19935656).
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Derived from site: In situ; Skin; UBERON=UBERON_0002097.
CC   Cell type: Fibroblast of skin; CL=CL_0002620.
DI   NCIt; C61255; Lesch-Nyhan syndrome
DI   ORDO; Orphanet_510; Lesch-Nyhan syndrome
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_F127 ! GM02063
SX   Male
AG   5Y6M
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 23
//
RX   CelloPub=CLPUB00447;
RA   Mulivor R.A., Suchy S.F.;
RT   "1992/1993 catalog of cell lines. NIGMS human genetic mutant cell
RT   repository. 16th edition. October 1992.";
RL   (In) Institute for Medical Research (Camden, N.J.) NIH 92-2011; pp.1-918; National Institutes of Health; Bethesda (1992).
//
RX   CelloPub=CLPUB00712;
RA   Henson J.D.;
RT   "The role of alternative lengthening of telomeres in human cancer.";
RL   Thesis PhD (2006), University of Sydney, Australia.
//
RX   DOI=10.5962/bhl.title.4090;
RA   Coriell L.L., Greene A.E.;
RT   "The human genetic mutant cell repository: list of genetic variants,
RT   chromosomal aberrations and normal cell cultures submitted to the
RT   repository. 4th edition. October 1977.";
RL   (In) Institute for Medical Research (Camden, N.J.); pp.1-171; National Institutes of Health; Bethesda (1977).
//
RX   PubMed=174085; DOI=10.1073/pnas.72.12.4971;
RA   Stiles C.D., Desmond W. Jr., Sato G.H., Saier M.H. Jr.;
RT   "Failure of human cells transformed by simian virus 40 to form tumors
RT   in athymic nude mice.";
RL   Proc. Natl. Acad. Sci. U.S.A. 72:4971-4975(1975).
//
RX   PubMed=191830; DOI=10.1073/pnas.74.3.1142;
RA   Koprowski H., Croce C.M.;
RT   "Tumorigenicity of simian virus 40-transformed human cells and
RT   mouse-human hybrids in nude mice.";
RL   Proc. Natl. Acad. Sci. U.S.A. 74:1142-1146(1977).
//
RX   PubMed=1260760;
RA   Stiles C.D., Desmond W. Jr., Chuman L.M., Sato G.H., Saier M.H. Jr.;
RT   "Growth control of heterologous tissue culture cells in the
RT   congenitally athymic nude mouse.";
RL   Cancer Res. 36:1353-1360(1976).
//
RX   PubMed=3413074; DOI=10.1073/pnas.85.16.6042;
RA   Pereira-Smith O.M., Smith J.R.;
RT   "Genetic analysis of indefinite division in human cells:
RT   identification of four complementation groups.";
RL   Proc. Natl. Acad. Sci. U.S.A. 85:6042-6046(1988).
//
RX   PubMed=9175740; DOI=10.1093/hmg/6.6.921;
RA   Bryan T.M., Marusic L., Bacchetti S., Namba M., Reddel R.R.;
RT   "The telomere lengthening mechanism in telomerase-negative immortal
RT   human cells does not involve the telomerase RNA subunit.";
RL   Hum. Mol. Genet. 6:921-926(1997).
//
RX   PubMed=11359895; DOI=10.1128/mcb.21.12.3862-3875.2001;
RA   Perrem K., Colgin L.M., Neumann A.A., Yeager T.R., Reddel R.R.;
RT   "Coexistence of alternative lengthening of telomeres and telomerase in
RT   hTERT-transfected GM847 cells.";
RL   Mol. Cell. Biol. 21:3862-3875(2001).
//
RX   PubMed=12361951; DOI=10.1074/jbc.M207937200;
RA   Donahue S.L., Campbell C.;
RT   "A DNA double strand break repair defect in Fanconi anemia
RT   fibroblasts.";
RL   J. Biol. Chem. 277:46243-46247(2002).
//
RX   PubMed=19935656; DOI=10.1038/nbt.1587;
RA   Henson J.D., Cao Y., Huschtscha L.I., Chang A.C.-M., Au A.Y.M.,
RA   Pickett H.A., Reddel R.R.;
RT   "DNA C-circles are specific and quantifiable markers of
RT   alternative-lengthening-of-telomeres activity.";
RL   Nat. Biotechnol. 27:1181-1185(2009).
//
RX   PubMed=26001292; DOI=10.18632/oncotarget.3846;
RA   Napier C.E., Huschtscha L.I., Harvey A., Bower K., Noble J.R.,
RA   Hendrickson E.A., Reddel R.R.;
RT   "ATRX represses alternative lengthening of telomeres.";
RL   Oncotarget 6:16543-16558(2015).
//