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Cellosaurus Huh-7.5 (CVCL_7927)

[Text version]

Cell line name Huh-7.5
Synonyms Huh 7.5; Huh7.5
Accession CVCL_7927
Resource Identification Initiative To cite this cell line use: Huh-7.5 (RRID:CVCL_7927)
Comments Part of: ENCODE project common cell types; tier 3.
Population: Japanese.
Omics: Deep proteome analysis.
Sequence variations Homozygous for DDX58 p.Thr55Ile (c.164C>T) (PubMed=15708988).
Homozygous for KDR p.Gln472His (c.1416A>T) (from parent cell line).
POLD3 p.Lys70Arg (c.209A>G) (from parent cell line).
TERT c.228C>T (-124C>T); in promoter (from parent cell line).
Homozygous for TP53 p.Tyr220Cys (c.659A>G) (ClinVar=VCV000127819) (from parent cell line).
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0336 (Huh-7)
CVCL_E049 (Huh-7.5.1)
Sex of cell Male
Age at sampling 57Y
Category Cancer cell line
Web pages http://genome.ucsc.edu/ENCODE/protocols/cell/human/Huh-7.5_Crawford_protocol.pdf

PubMed=12438626; DOI=10.1128/JVI.76.24.13001-13014.2002
Blight K.J., McKeating J.A., Rice C.M.
Highly permissive cell lines for subgenomic and genomic hepatitis C virus RNA replication.
J. Virol. 76:13001-13014(2002)

PubMed=15708988; DOI=10.1128/JVI.79.5.2689-2699.2005
Sumpter R. Jr., Loo Y.-M., Foy E., Li K., Yoneyama M., Fujita T., Lemon S.M., Gale M. Jr.
Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I.
J. Virol. 79:2689-2699(2005)

PubMed=17079281; DOI=10.1128/JVI.01534-06
Koutsoudakis G., Herrmann E., Kallis S., Bartenschlager R., Pietschmann T.
The level of CD81 cell surface expression is a key determinant for productive entry of hepatitis C virus into host cells.
J. Virol. 81:588-598(2007)

PubMed=17552027; DOI=10.3748/wjg.v13.i17.2442
Duverlie G., Wychowski C.
Cell culture systems for the hepatitis C virus.
World J. Gastroenterol. 13:2442-2445(2007)

Cell line databases/resources Lonza; 1432
Ontologies BTO; BTO:0004126
EFO; EFO_0005704
Biological sample resources ENCODE; ENCBS227AAA
Gene expression databases GEO; GSM816671
Other Wikidata; Q54896856
Proteomic databases PRIDE; PXD006386
Entry history
Entry creation04-Apr-2012
Last entry update02-Jul-2020
Version number18