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Cellosaurus 21MT-2 (CVCL_7932)

[Text version]
Cell line name 21MT-2
Synonyms 21-MT-2; 21MT2
Accession CVCL_7932
Resource Identification Initiative To cite this cell line use: 21MT-2 (RRID:CVCL_7932)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: GrayJW breast cancer cell line panel.
Characteristics: 21PT is non-tumorigenic whereas 21NT and 21MT-1/21-MT-2 cause tumors in the nude mice system.
Doubling time: 42.0 +- 2.5 hours (Note=In alpha H&E medium), 42.3 +- 4.7 hours (Note=In D medium) (PubMed=8482634).
Omics: Deep exome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Ser33Phefs*9 (c.96_97insT); Zygosity=Unspecified (PubMed=7923592).
HLA typing Source: PubMed=25960936
Class I
HLA-AA*26:01,31:01
HLA-BB*35:02,38:01
HLA-CC*04:01,12:03
Class II
HLA-DRDRB1*04:03,04:03
Disease Breast carcinoma (NCIt: C4872)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_7931 ! 21MT-1
CVCL_7933 ! 21NT
CVCL_7934 ! 21PT
CVCL_IP81 ! H16F1
CVCL_IP82 ! H16N-2
CVCL_IP83 ! H16N-3
Sex of cell Female
Age at sampling 37Y
Category Cancer cell line
Web pages https://www.synapse.org/#!Synapse:syn2346643/wiki/62255
Publications

DOI=10.1007/978-1-4612-0411-4_18
Band V., Sager R.
Tumor progression in breast cancer.
(In) Neoplastic transformation in human cell system. Mechanism of carcinogenesis; Rhim J.S., Dritschilo A. (eds.); pp.169-178; Humana Press; New York (1990)

PubMed=1977518
Band V., Zajchowski D., Swisshelm K.L., Trask D.K., Kulesa V., Cohen C., Connolly J.L., Sager R.
Tumor progression in four mammary epithelial cell lines derived from the same patient.
Cancer Res. 50:7351-7357(1990)

PubMed=8482634; DOI=10.1016/0360-3016(93)90176-V
Wazer D.E., Joyce M., Jung L., Band V.
Alterations in growth phenotype and radiosensitivity after fractionated irradiation of breast carcinoma cells from a single patient.
Int. J. Radiat. Oncol. Biol. Phys. 26:81-88(1993)

DOI=10.1016/B978-0-12-333530-2.50009-5
Leibovitz A.
Cell lines from human breast.
(In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.161-184; Academic Press; New York (1994)

PubMed=7923592; DOI=10.1093/carcin/15.9.1969
Liu X.-L., Band H., Gao Q.-S., Wazer D.E., Chu Q.-M., Band V.
Tumor cell-specific loss of p53 protein in a unique in vitro model of human breast tumor progression.
Carcinogenesis 15:1969-1973(1994)

PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110
Daemen A., Griffith O.L., Heiser L.M., Wang N.J., Enache O.M., Sanborn Z., Pepin F., Durinck S., Korkola J.E., Griffith M., Hur J.S., Huh N., Chung J., Cope L., Fackler M.J., Umbricht C.B., Sukumar S., Seth P., Sukhatme V.P., Jakkula L.R., Lu Y.-L., Mills G.B., Cho R.J., Collisson E.A., van 't Veer L.J., Spellman P.T., Gray J.W.
Modeling precision treatment of breast cancer.
Genome Biol. 14:R110.1-R110.14(2013)

PubMed=25960936; DOI=10.4161/21624011.2014.954893
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)

Cross-references
Cell line databases/resources Cell_Model_Passport; SIDM01901
DepMap; ACH-002401
Chemistry resources PharmacoDB; 21MT2_9_2019
Encyclopedic resources Wikidata; Q54583258
Gene expression databases GEO; GSM1172935
GEO; GSM1172847
GEO; GSM3145687
Polymorphism and mutation databases IARC_TP53; 21721
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number21