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Cellosaurus 21NT (CVCL_7933)

[Text version]

Cell line name 21NT
Synonyms 21 NT
Accession CVCL_7933
Resource Identification Initiative To cite this cell line use: 21NT (RRID:CVCL_7933)
Comments Part of: GrayJW Breast Cancer Cell Line Panel.
Characteristics: 21PT is non-tumorigenic whereas 21NT and 21MT-1/21-MT-2 cause tumors in the nude mice system.
Doubling time: 31.4 +- 2.6 hours (in alpha H&E medium), 38.6 +- 2.9 hours (in D medium) (PubMed=8482634); 46.38 hours (https://www.synapse.org/#!Synapse:syn2347014).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Sequence variations TP53 p.Ser33Phefs*9 (c.96_97insT) (PubMed=7923592).
HLA typing Source: PubMed=25960936
Class I
HLA-AA*31:01,26:01
HLA-BB*38:01,35:02
HLA-CC*04:01,12:03
Class II
HLA-DRDRB1*04:03,04:03
Disease Breast carcinoma (NCIt: C4872)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_7931 ! 21MT-1
CVCL_7932 ! 21MT-2
CVCL_7934 ! 21PT
CVCL_IP81 ! H16F1
CVCL_IP82 ! H16N-2
CVCL_IP83 ! H16N-3
Sex of cell Female
Age at sampling 36Y
Category Cancer cell line
Web pages https://www.synapse.org/#!Synapse:syn2346643/wiki/62255
Publications

DOI=10.1007/978-1-4612-0411-4_18
Band V., Sager R.
Tumor progression in breast cancer.
(In) Neoplastic transformation in human cell system. Mechanism of carcinogenesis; Rhim J.S., Dritschilo A. (eds.); pp.169-178; Humana Press; New York (1990)

PubMed=1977518
Band V., Zajchowski D., Swisshelm K., Trask D., Kulesa V., Cohen C., Connolly J., Sager R.
Tumor progression in four mammary epithelial cell lines derived from the same patient.
Cancer Res. 50:7351-7357(1990)

PubMed=8482634; DOI=10.1016/0360-3016(93)90176-V
Wazer D.E., Joyce M., Jung L., Band V.
Alterations in growth phenotype and radiosensitivity after fractionated irradiation of breast carcinoma cells from a single patient.
Int. J. Radiat. Oncol. Biol. Phys. 26:81-88(1993)

DOI=10.1016/B978-0-12-333530-2.50009-5
Leibovitz A.
Cell lines from human breast.
(In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.161-184; Academic Press; New York (1994)

PubMed=7923592; DOI=10.1093/carcin/15.9.1969
Liu X.-L., Band H., Gao Q., Wazer D.E., Chu Q., Band V.
Tumor cell-specific loss of p53 protein in a unique in vitro model of human breast tumor progression.
Carcinogenesis 15:1969-1973(1994)

PubMed=20458274; DOI=10.1038/labinvest.2010.97
Souter L.H., Andrews J.D., Zhang G., Cook A.C., Postenka C.O., Al-Katib W., Leong H.S., Rodenhiser D.I., Chambers A.F., Tuck A.B.
Human 21T breast epithelial cell lines mimic breast cancer progression in vivo and in vitro and show stage-specific gene expression patterns.
Lab. Invest. 90:1247-1258(2010)

PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110
Daemen A., Griffith O.L., Heiser L.M., Wang N.J., Enache O.M., Sanborn Z., Pepin F., Durinck S., Korkola J.E., Griffith M., Hur J.S., Huh N., Chung J., Cope L., Fackler M.J., Umbricht C., Sukumar S., Seth P., Sukhatme V.P., Jakkula L.R., Lu Y., Mills G.B., Cho R.J., Collisson E.A., van't Veer L.J., Spellman P.T., Gray J.W.
Modeling precision treatment of breast cancer.
Genome Biol. 14:R110.1-R110.14(2013)

PubMed=25960936; DOI=10.4161/21624011.2014.954893
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:E954893-E954893(2014)

Cross-references
Cell line databases/resources LINCS_HMS; 51108
Chemistry resources PharmacoDB; 21NT_10_2019
Gene expression databases GEO; GSM1172936
GEO; GSM1172848
GEO; GSM1664566
Other Wikidata; Q54583260
Polymorphism and mutation databases IARC_TP53; 21719
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number14