ID   253J
AC   CVCL_7935
AS   CVCL_7938
SY   253j; 253-J; 253 J; 253J-P; 253J-Parental; 253J P; 253JP
DR   BTO; BTO:0004796
DR   ArrayExpress; E-MTAB-2770
DR   ATCC; HTB-108
DR   BioSample; SAMN10987961
DR   cancercelllines; CVCL_7935
DR   Cell_Model_Passport; SIDM01529
DR   Cosmic; 715794
DR   Cosmic; 760476
DR   Cosmic; 845564
DR   Cosmic; 925827
DR   Cosmic; 928820
DR   Cosmic; 1016884
DR   Cosmic; 1046680
DR   Cosmic; 1082644
DR   Cosmic; 1938694
DR   Cosmic; 1285102
DR   Cosmic; 1285997
DR   Cosmic; 1927305
DR   Cosmic; 2050426
DR   Cosmic; 2057433
DR   Cosmic; 2444255
DR   Cosmic; 2685929
DR   Cosmic; 2700994
DR   DepMap; ACH-000011
DR   GEO; GSM136240
DR   GEO; GSM1574546
DR   GEO; GSM1574574
DR   IARC_TP53; 21034
DR   KCLB; 80001
DR   LiGeA; CCLE_259
DR   PharmacoDB; 253J_14_2019
DR   Wikidata; Q54583653
RX   DOI=10.1016/B978-0-12-043050-5.50049-4;
RX   PubMed=66978;
RX   PubMed=327080;
RX   PubMed=571047;
RX   PubMed=748774;
RX   PubMed=944089;
RX   PubMed=3518877;
RX   PubMed=3708594;
RX   PubMed=4431054;
RX   PubMed=6244232;
RX   PubMed=6582512;
RX   PubMed=6935474;
RX   PubMed=7459858;
RX   PubMed=7658585;
RX   PubMed=8873383;
RX   PubMed=11207054;
RX   PubMed=11416159;
RX   PubMed=11921286;
RX   PubMed=12127398;
RX   PubMed=15846775;
RX   PubMed=16885334;
RX   PubMed=23401075;
RX   PubMed=24035680;
RX   PubMed=24367658;
RX   PubMed=25997541;
RX   PubMed=26589293;
RX   PubMed=26621286;
RX   PubMed=27270441;
RX   PubMed=29732388;
RX   PubMed=31068700;
WW   https://www.synapse.org/UC25
CC   Part of: BLA-40 bladder carcinoma cell line panel.
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: UBC-40 urothelial bladder cancer cell line index.
CC   Population: Caucasian.
CC   Doubling time: 36 hours (PubMed=66978; PubMed=748774); 46 +- 3 hours (PubMed=7658585); 28 hours (PubMed=3708594).
CC   HLA typing: A*01:01,03:01; B*08:01,51:01; C*07:01,12:03 (PubMed=26589293).
CC   Microsatellite instability: Stable (MSS) (PubMed=31068700).
CC   Omics: CNV analysis.
CC   Omics: Deep exome analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Discontinued: ATCC; HTB-108; true.
CC   Derived from site: Metastatic; Retroperitoneal lymph node; UBERON=UBERON_0035371.
ST   Source(s): KCLB; PubMed=11416159; PubMed=27270441
ST   Amelogenin: X
ST   CSF1PO: 10,12
ST   D13S317: 9
ST   D16S539: 9,12
ST   D18S51: 11,13
ST   D21S11: 28,29
ST   D3S1358: 15
ST   D5S818: 10,12
ST   D7S820: 9
ST   D8S1179: 11
ST   FGA: 23,24
ST   TH01: 6,9.3
ST   TPOX: 8,11
ST   vWA: 17,18
DI   NCIt; C4912; Bladder carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   53Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 29
//
RX   DOI=10.1016/B978-0-12-043050-5.50049-4;
RA   Elliott A.Y., Bronson D.L., Cervenka J., Cleveland P.H., Fraley E.E.;
RT   "Establishment and characterization of epithelial cell cultures from
RT   tumors of the human urinary tract.";
RL   (In) Cell culture and the application; Acton R. (eds.); pp.711-728; Academic Press; New York (1977).
//
RX   PubMed=66978;
RA   Elliott A.Y., Bronson D.L., Cervenka J., Stein N., Fraley E.E.;
RT   "Properties of cell lines established from transitional cell cancers
RT   of the human urinary tract.";
RL   Cancer Res. 37:1279-1289(1977).
//
RX   PubMed=327080; DOI=10.1093/jnci/59.1.221;
RA   Fogh J., Fogh J.M., Orfeo T.;
RT   "One hundred and twenty-seven cultured human tumor cell lines
RT   producing tumors in nude mice.";
RL   J. Natl. Cancer Inst. 59:221-226(1977).
//
RX   PubMed=571047;
RA   Fogh J.;
RT   "Cultivation, characterization, and identification of human tumor
RT   cells with emphasis on kidney, testis, and bladder tumors.";
RL   Natl. Cancer Inst. Monogr. 49:5-9(1978).
//
RX   PubMed=748774;
RA   Elliott A.Y., Bronson D.L., Fraley E.E.;
RT   "Transitional cell cancer: establishment and characterization of cell
RT   lines.";
RL   Natl. Cancer Inst. Monogr. 49:23-24(1978).
//
RX   PubMed=944089;
RA   Elliott A.Y., Bronson D.L., Stein N., Fraley E.E.;
RT   "In vitro cultivation of epithelial cells derived from tumors of the
RT   human urinary tract.";
RL   Cancer Res. 36:365-369(1976).
//
RX   PubMed=3518877; DOI=10.3109/07357908609038260;
RA   Fogh J.;
RT   "Human tumor lines for cancer research.";
RL   Cancer Invest. 4:157-184(1986).
//
RX   PubMed=3708594;
RA   Masters J.R.W., Hepburn P.J., Walker L., Highman W.J.,
RA   Trejdosiewicz L.K., Povey S., Parkar M., Hill B.T., Riddle P.N.,
RA   Franks L.M.;
RT   "Tissue culture model of transitional cell carcinoma: characterization
RT   of twenty-two human urothelial cell lines.";
RL   Cancer Res. 46:3630-3636(1986).
//
RX   PubMed=4431054; DOI=10.1093/jnci/53.5.1341;
RA   Elliott A.Y., Cleveland P.H., Cervenka J., Castro A.E., Stein N.,
RA   Hakala T.R., Fraley E.E.;
RT   "Characterization of a cell line from human transitional cell cancer
RT   of the urinary tract.";
RL   J. Natl. Cancer Inst. 53:1341-1349(1974).
//
RX   PubMed=6244232;
RA   Williams R.D.;
RT   "Human urologic cancer cell lines.";
RL   Invest. Urol. 17:359-363(1980).
//
RX   PubMed=6582512; DOI=10.1073/pnas.81.2.568;
RA   Mattes M.J., Cordon-Cardo C., Lewis J.L. Jr., Old L.J., Lloyd K.O.;
RT   "Cell surface antigens of human ovarian and endometrial carcinoma
RT   defined by mouse monoclonal antibodies.";
RL   Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984).
//
RX   PubMed=6935474; DOI=10.1093/jnci/66.2.239;
RA   Wright W.C., Daniels W.P., Fogh J.;
RT   "Distinction of seventy-one cultured human tumor cell lines by
RT   polymorphic enzyme analysis.";
RL   J. Natl. Cancer Inst. 66:239-247(1981).
//
RX   PubMed=7459858;
RA   Rousset M., Zweibaum A., Fogh J.;
RT   "Presence of glycogen and growth-related variations in 58 cultured
RT   human tumor cell lines of various tissue origins.";
RL   Cancer Res. 41:1165-1170(1981).
//
RX   PubMed=7658585; DOI=10.1016/S0022-5347(01)66923-4;
RA   Dinney C.P.N., Fishbeck R., Singh R.K., Eve B., Pathak S., Brown N.,
RA   Xie B., Fan D., Bucana C.D., Fidler I.J., Killion J.J.;
RT   "Isolation and characterization of metastatic variants from human
RT   transitional cell carcinoma passaged by orthotopic implantation in
RT   athymic nude mice.";
RL   J. Urol. 154:1532-1538(1995).
//
RX   PubMed=8873383; DOI=10.1007/BF00295899;
RA   Stadler W.M., Olopade O.I.;
RT   "The 9p21 region in bladder cancer cell lines: large homozygous
RT   deletion inactivate the CDKN2, CDKN2B and MTAP genes.";
RL   Urol. Res. 24:239-244(1996).
//
RX   PubMed=11207054; DOI=10.1054/bjoc.2000.1641;
RA   Fujiyama C., Jones A., Fuggle S., Bicknell R., Cranston D.,
RA   Harris A.L.;
RT   "Human bladder cancer invasion model using rat bladder in vitro and
RT   its use to test mechanisms and therapeutic inhibitors of invasion.";
RL   Br. J. Cancer 84:558-564(2001).
//
RX   PubMed=11416159; DOI=10.1073/pnas.121616198;
RA   Masters J.R.W., Thomson J.A., Daly-Burns B., Reid Y.A., Dirks W.G.,
RA   Packer P., Toji L.H., Ohno T., Tanabe H., Arlett C.F., Kelland L.R.,
RA   Harrison M., Virmani A.K., Ward T.H., Ayres K.L., Debenham P.G.;
RT   "Short tandem repeat profiling provides an international reference
RT   standard for human cell lines.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001).
//
RX   PubMed=11921286; DOI=10.1002/gcc.10050;
RA   Williams S.V., Sibley K.D., Davies A.M., Nishiyama H., Hornigold N.,
RA   Coulter J., Kennedy W.J., Skilleter A., Habuchi T., Knowles M.A.;
RT   "Molecular genetic analysis of chromosome 9 candidate tumor-suppressor
RT   loci in bladder cancer cell lines.";
RL   Genes Chromosomes Cancer 34:86-96(2002).
//
RX   PubMed=12127398; DOI=10.1016/S0165-4608(01)00648-3;
RA   Strefford J.C., Lillington D.M., Steggall M., Lane T.M., Nouri A.M.E.,
RA   Young B.D., Oliver R.T.D.;
RT   "Novel chromosome findings in bladder cancer cell lines detected with
RT   multiplex fluorescence in situ hybridization.";
RL   Cancer Genet. Cytogenet. 135:139-146(2002).
//
RX   PubMed=15846775; DOI=10.1002/gcc.20166;
RA   Williams S.V., Adams J., Coulter J., Summersgill B.M., Shipley J.M.,
RA   Knowles M.A.;
RT   "Assessment by M-FISH of karyotypic complexity and cytogenetic
RT   evolution in bladder cancer in vitro.";
RL   Genes Chromosomes Cancer 43:315-328(2005).
//
RX   PubMed=16885334; DOI=10.1158/0008-5472.CAN-06-1182;
RA   Lopez-Knowles E., Hernandez S., Malats N., Kogevinas M., Lloreta J.,
RA   Carrato A., Tardon A., Serra C., Real F.X.;
RT   "PIK3CA mutations are an early genetic alteration associated with
RT   FGFR3 mutations in superficial papillary bladder tumors.";
RL   Cancer Res. 66:7401-7404(2006).
//
RX   PubMed=23401075; DOI=10.1002/path.4176;
RA   Guo Y.-N., Chekaluk Y., Zhang J.-M., Du J.-Y., Gray N.S., Wu C.-L.,
RA   Kwiatkowski D.J.;
RT   "TSC1 involvement in bladder cancer: diverse effects and therapeutic
RT   implications.";
RL   J. Pathol. 230:17-27(2013).
//
RX   PubMed=24035680; DOI=10.1016/j.eururo.2013.08.057;
RA   Hurst C.D., Platt F.M., Knowles M.A.;
RT   "Comprehensive mutation analysis of the TERT promoter in bladder
RT   cancer and detection of mutations in voided urine.";
RL   Eur. Urol. 65:367-369(2014).
//
RX   PubMed=24367658; DOI=10.1371/journal.pone.0084411;
RA   Ross R.L., Burns J.E., Taylor C.F., Mellor P., Anderson D.H.,
RA   Knowles M.A.;
RT   "Identification of mutations in distinct regions of p85 alpha in
RT   urothelial cancer.";
RL   PLoS ONE 8:E84411-E84411(2013).
//
RX   PubMed=25997541; DOI=10.1186/s12864-015-1450-3;
RA   Earl J., Rico D., Carrillo-de-Santa-Pau E., Rodriguez-Santiago B.,
RA   Mendez-Pertuz M., Auer H., Gomez G., Grossman H.B., Pisano D.G.,
RA   Schulz W.A., Perez-Jurado L.A., Carrato A., Theodorescu D.,
RA   Chanock S.J., Valencia A., Real F.X.;
RT   "The UBC-40 Urothelial Bladder Cancer cell line index: a genomic
RT   resource for functional studies.";
RL   BMC Genomics 16:403.1-403.16(2015).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5;
RA   Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P.,
RA   Loewer M., Sahin U., Castle J.C.;
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=26621286; DOI=10.1186/s12864-015-2227-4;
RA   Earl J., Rico D., Carrillo-de-Santa-Pau E., Rodriguez-Santiago B.,
RA   Mendez-Pertuz M., Auer H., Gomez G., Grossman H.B., Pisano D.G.,
RA   Schulz W.A., Perez-Jurado L.A., Carrato A., Theodorescu D.,
RA   Chanock S.J., Valencia A., Real F.X.;
RT   "Erratum to: The UBC-40 Urothelial Bladder Cancer cell line index: a
RT   genomic resource for functional studies.";
RL   BMC Genomics 16:1019.1-1019.2(2015).
//
RX   PubMed=27270441; DOI=10.1038/onc.2016.172;
RA   Nickerson M.L., Witte N., Im K.M., Turan S., Owens C., Misner K.,
RA   Tsang S.X., Cai Z., Wu S., Dean M., Costello J.C., Theodorescu D.;
RT   "Molecular analysis of urothelial cancer cell lines for modeling tumor
RT   biology and drug response.";
RL   Oncogene 36:35-46(2017).
//
RX   PubMed=29732388; DOI=10.3233/BLC-180167;
RA   Zuiverloon T.C.M., de Jong F.C., Costello J.C., Theodorescu D.;
RT   "Systematic review: characteristics and preclinical uses of bladder
RT   cancer cell lines.";
RL   Bladder Cancer 4:169-183(2018).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//