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Cellosaurus HAK-1A (CVCL_7957)

[Text version]
Cell line name HAK-1A
Accession CVCL_7957
Resource Identification Initiative To cite this cell line use: HAK-1A (RRID:CVCL_7957)
Comments Population: Japanese.
Doubling time: 27 hours (Note=At 8th passage) (PubMed=8393423).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Cys242Tyr (c.725G>A); ClinVar=VCV000012354; Zygosity=Unspecified (PubMed=8393423).
Disease Hepatitis C infection (NCIt: C3098)
Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_7958 ! HAK-1B
Sex of cell Male
Age at sampling 55Y
Category Cancer cell line
Publications

PubMed=8393423; DOI=10.1002/hep.1840180216
Yano H., Iemura A., Fukuda K., Mizoguchi A., Haramaki M., Kojiro M.
Establishment of two distinct human hepatocellular carcinoma cell lines from a single nodule showing clonal dedifferentiation of cancer cells.
Hepatology 18:320-327(1993)

PubMed=7537711; DOI=10.1002/hep.1840210510
Haramaki M., Yano H., Fukuda K., Momosaki S., Ogasawara S., Kojiro M.
Expression of CD44 in human hepatocellular carcinoma cell lines.
Hepatology 21:1276-1284(1995)

PubMed=10347112; DOI=10.1002/hep.510290624
Yano H., Iemura A., Haramaki M., Ogasawara S., Takayama A., Akiba J., Kojiro M.
Interferon alfa receptor expression and growth inhibition by interferon alfa in human liver cancer cell lines.
Hepatology 29:1708-1717(1999)

PubMed=27329724; DOI=10.18632/oncotarget.10161
Watari K., Nishitani A., Shibata T., Noda M., Kawahara A., Akiba J., Murakami Y., Yano H., Kuwano M., Ono M.
Phosphorylation of mTOR Ser2481 is a key target limiting the efficacy of rapalogs for treating hepatocellular carcinoma.
Oncotarget 7:47403-47417(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_7957
Encyclopedic resources Wikidata; Q54872378
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number18