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Cellosaurus HPB-MLT (CVCL_7959)

[Text version]

Cell line name HPB-MLT
Synonyms FCCH1019
Accession CVCL_7959
Resource Identification Initiative To cite this cell line use: HPB-MLT (RRID:CVCL_7959)
Comments Problematic cell line: Contaminated. Shown to be a HPB-ALL derivative (PubMed=12592342; PubMed=20143388).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00212.
Misspelling: MPB-MLT; In PubMed=10071127.
Derived from sampling site: Peripheral blood.
Sequence variations Heterozygous for NOTCH1 p.Leu1574Pro (c.4721T>C) and p.Asp2443fs*39 (c.7329_7329insGGGCCGTGGACG) (from parent cell line).
TP53 p.Cys124Ter (c.372C>A) (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1820 (HPB-ALL)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
STR profile Source(s): TKG


Run an STR similarity search on this cell line
Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations_v9_distribution.xlsx

PubMed=203546; DOI=10.1002/ijc.2910210207
Morikawa S., Tatsumi E., Baba M., Harada T., Yasuhira K.
Two E-rosette-forming lymphoid cell lines.
Int. J. Cancer 21:166-170(1978)

PubMed=1370437; DOI=10.1002/ijc.2910500223
Treichel R.S., Olken S.
The relationship between multi-drug resistance and resistance to natural-killer-cell and lymphokine-activated killer-cell lysis in human leukemic cell lines.
Int. J. Cancer 50:305-310(1992)

Duan D.-S., Smith W., Sadee W., Cowan M.J.
Characterization of three T-lymphoid cell lines with distinct sensitivities to deoxyadenosine plus deoxycoformycin.
Thymus 19:1-11(1992)

PubMed=8099376; DOI=10.1016/0145-2126(93)90124-4
Treichel R.S.
Autologous bone marrow transplantation for leukemia: monoclonal antibody-mediated purging of multidrug-resistant leukemia.
Leuk. Res. 17:491-499(1993)

PubMed=10071127; DOI=10.1016/S0145-2126(98)00146-5
Kawamura M., Ohnishi H., Guo S.X., Sheng X.M., Minegishi M., Hanada R., Horibe K., Hongo T., Kaneko Y., Bessho F., Yanagisawa M., Sekiya T., Hayashi Y.
Alterations of the p53, p21, p16, p15 and RAS genes in childhood T-cell acute lymphoblastic leukemia.
Leuk. Res. 23:115-126(1999)

PubMed=12592342; DOI=10.1038/sj.leu.2402799
Drexler H.G., Dirks W.G., Matsuo Y., MacLeod R.A.F.
False leukemia-lymphoma cell lines: an update on over 500 cell lines.
Leukemia 17:416-426(2003)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cell line collections RCB; RCB1937 - Discontinued
TKG; TKG 0361
Biological sample resources BioSample; SAMN03151780
Other Wikidata; Q54890237
Polymorphism and mutation databases Cosmic; 721703
Cosmic; 801733
Cosmic; 998731